Recombinant Protein

SIRPA / CD172a

Human

Unmodified

38.31 kDa

Mammalian Cells

Mammal

Greater than 95% by SDS-PAGE

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

The ED50 as determined by its ability to bind Human CD47 in functional ELISA is less than 0.5 ug/ml

Less than 1.0 EU/µg protein (determined by LAL method).

Lyophilized from 0.2 µm filtered 20 mM PBs, pH 7.2, 150 mM NaCl

Store at -80°C for up to 1 year. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This protein carries the LSBio 100% Guarantee.

Uniprot: P78324 NCBI: NM_080792 NP_542970.1