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Human Securin / PTTG1 Recombinant Protein LS-G45577

Ordering

Wt. Vol. Conc. Price
5 µg - - $225
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)
206-374-1102
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Most Popular Securin / PTTG1 Proteins

Human Securin / PTTG1 Recombinant (His) Protein - LS-G586
E. coli Expression System
His
Unpurified / Lyophilized / Endotoxin Level: Less than 0.5 EU/µg protein (determined by LAL method).
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Human Securin / PTTG1 Recombinant (His) Protein - LS-G20115
E. coli Expression System
His
Unpurified / Lyophilized
Mouse Securin / PTTG1 Recombinant (His + T7) Protein - LS-G25071
E. coli Expression System
His + T7
Unpurified

100% Guaranteed 100% Guaranteed
LS-G45577
Recombinant Protein
Securin / PTTG1
Human
MGSSHHHHHH SSGLVPRGSH MATLIYVDKE NGEPGTRVVA
KDGLKLGSGP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT
RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA
KSSVPASDDA YPEIEKFFPF NPLDFESFDL PEEHQIAHLP
LSGVPLMILD EERELEKLFQ LGPPSPVKMP SPPWESNLLQ
SPSSILSTLD VELPPVCCDI DI
E. coli
None
Greater than 80% by SDS-PAGE
20 mM Tris HCl, pH 8.0, 0.1 M NaCl, transforming gene, 10% glycerol
For research use only.

About Securin / PTTG1

O95997 NM_004219 NP_004210.1

PTTG1 Protein, EAP1 Protein, Esp1-associated protein Protein, HPTTG Protein, ESP1-associated protein 1 Protein, Pituitary tumor-transforming 1 Protein, TUTR1 Protein, PTTG Protein, Securin Protein, Tumor-transforming protein 1 Protein

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1.

Requested From: United States
Date Requested: 12/3/2016

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