IL6R / IL6 Receptor Protein LS-G27255 is Recombinant Human IL6R / IL6 Receptor in Spodoptera frugiperda with His, N-Terminal tag(s). It is biologically active and is low in endotoxin Less than 0.2 EU/µg protein (determined by LAL method)..
IL6R / IL6 Receptor
Predicted Molecular Weight
50 kDa (SDS-PAGE)
Interleukin-6 Receptor (IL-6R) is a single trans-membrane protein that is the receptor for Interleukin-6 (IL-6). IL-6R forms a hexameric complex upon binding 2 molecules of IL-6 and two molecules of glycoprotein 130 (gp130) which activates intracellular JAK/STAT pathways. Although the normal form of IL-6R is the membrane-bound 80 kDa subunit, a soluble form of IL-6R (sIL-6R) can be generated physiologically by limited proteolysis or alternative splicing. sIL-6R binds to both IL-6 and gp130 generating intracellular signaling. In the immune system, sIL-6R is produced by both naive and memory CD4 T-cells and strongly augments IL-6 ligand's induction of Th-17 cells.Recombinant human Soluble IL-6 Receptor Alpha (rhsIL-6R alpha) with an N-terminal His tag produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 350 amino acids. A fully biologically active molecule, rhsIL-6R alpha has a molecular mass of 50kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Greater than 95% by non-reducing SDS-PAGE and HPLC
ED50 < 50ng/mL, as determined by the cytotoxicity assay using M1 cells in presence of 10 ng/mL of human IL-6, corresponding to a specific activity of > 2x104 units/mg.
Less than 0.2 EU/µg protein (determined by LAL method).
Lyophilized from PBS
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 2 weeks or at -20°c for up to 3 months.
For research use only.
About IL6R / IL6 Receptor