Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IL17RB is a type I transmembrane protein with 17% homology to IL17R. Studies have shown that IL17RB binds strongly to IL17E, weakly to IL17B but does not bind IL17 or IL17C. The IL17 proteins are a family of potent cytokines that act to induce proinflammatory responses. Receptor binding of ligand has been shown to lead to the activation of nuclear factor kappa-B and production of IL8.