Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
26.4 kDa. DTT-reduced protein migrates as 35 kDa due to glycosylation
HEK 293 Cells
Greater than 95% by SDS-PAGE
Measured by its ability to cleave a peptide substrate, t-Butyloxycaronyl-Ala-Ala-Asp-ThioBenzyl ester (Boc-AAD-SBzl), in the presence of 5, 5’-Dithio-bis (2-nitrobenzoic acid) (DTNB). The specific activity is more than 800 pmol/min/µg.
Less than 0.1 ng/µg of protein (less than 1EU/µg).
Lyophilized from PBS, 5-8% mannitol or trehalose
Centrifuge the vial before opening. Reconstitute in sterile PBS, pH 7.4 to 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, store at -20°C.
GZMB Protein, CCPI Protein, CGL-1 Protein, Cathepsin G-like 1 Protein, CSP-B Protein, CTLA-1 Protein, CTLA1 Protein, CGL1 Protein, CSPB Protein, Fragmentin 2 Protein, GRB Protein, HLP Protein, Human lymphocyte protein Protein, Fragmentin-2 Protein, SECT Protein, Lymphocyte protease Protein, T-cell serine protease 1-3E Protein, C11 Protein, CTSGL1 Protein, Cytotoxic serine protease B Protein, Granzyme B Protein, Granzyme-2 Protein
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.