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| Catalog Number | Size | Price |
|---|---|---|
| LS-G47433-100 | 100 µg | $480 |
| LS-G47433-1 | 1 mg | $2,324 |
Human ERBB2 / HER2 Protein (Recombinant His,C-terminus) (Met1-Thr652) - LS-G47433
Human ERBB2 / HER2 Protein (Recombinant His,C-terminus) (Met1-Thr652) - LS-G47433
Description:
ERBB2 / HER2 Protein LS-G47433 is a Recombinant Human ERBB2 / HER2 produced in HEK 293 Cells Met1-Thr652 with His,C-terminus tag(s). It is biologically active and is low in endotoxin; Less than 1.0 EU/µg protein (determined by LAL method). For Research Use Only
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Description:
ERBB2 / HER2 Protein LS-G47433 is a Recombinant Human ERBB2 / HER2 produced in HEK 293 Cells Met1-Thr652 with His,C-terminus tag(s). It is biologically active and is low in endotoxin; Less than 1.0 EU/µg protein (determined by LAL method). For Research Use Only
Specifications
Type
Recombinant Protein
Target
ERBB2 / HER2
Synonyms
ERBB2 | C-erb B2/neu protein | CD340 | HER2 | Herstatin | MLN 19 | HER-2 | Neu | NGL | Proto-oncogene c-ErbB-2 | Proto-oncogene Neu | CD340 antigen | MLN19 | p185erbB2 | TKR1
Species
Human
Modifications
Unmodified
Conjugations
Unconjugated
Applications
- Binding
- ELISA
- Functional Assay
- Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
Tag
His,C-terminus
Region
Met1-Thr652
Predicted Molecular Weight
The recombinant human ErbB2 comprises 641 amino acids and has a calculated molecular mass of 71 kDa. As a result of glycosylation, rh ErbB2 migrates as an approximately 100-110 kDa protein in SDS-PAGE under reducing conditions.
Expression System
HEK 293 Cells
Source Species
Human
Purification
> 90 % as determined by SDS-PAGE
Bio-Activity
Measured by its binding ability in a functional ELISA.Immobilized human Erbb2 at 2.5 µg/ml (100 µl/well) can bind Herceptin with a linear ranger of 1.28-32 ng/ml. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED50 for this effect is 0.3-1.8 µg/mL in the presence of 0.6 µg/mL Anti-ErbB2/Her2 Monoclonal Antibody.
Endotoxin
Less than 1.0 EU/µg protein (determined by LAL method).
Presentation
Lyophilized from sterile PBS, pH 7.4, with 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Reconstitution
Please refer to included instructions for detailed information.
Storage
Aliquot and store at -20°C to -80°C for one year. Avoid repeated freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About ERBB2 / HER2
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Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/26/2024
Date Requested: 4/26/2024
