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Human EGLN3 / PHD3 Recombinant (His) Protein LS-G18802

Ordering

Wt. Vol. Conc. Price
2 µg - - $195
10 µg - - $255
100 µg - - $1,260
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Most Popular EGLN3 / PHD3 Proteins

Human EGLN3 / PHD3 Recombinant (His) Protein - LS-G1827
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Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Human EGLN3 / PHD3 Recombinant (His) Protein - LS-G18802
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His
Unpurified / Lyophilized
Mouse EGLN3 / PHD3 Recombinant (His) Protein - LS-G22646
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LS-G18802
Recombinant Protein
EGLN3 / PHD3
Human
29.8 kDa
EGLN3 Human Recombinant produced in E. coli is a single polypeptide chain containing 263 amino acids (1-239) and having a molecular mass of 29.8 kDa.EGLN3 is fused to a 24 amino acid His-tag at N-terminus and purified by proprietary chromatographic techniques.
E. coli
E. coli
His
Greater than 90% by SDS-PAGE
20 mM Tris-HCl, pH 8.0, 20 mM NaCl, 20 mM DTT, 20 mM EDTA, 50% glycerol.
Store lyophilized at 4°C. Once reconstituted, aliquot and store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About EGLN3 / PHD3

Q9H6Z9 NM_022073 NP_071356.1

EGLN3 Protein, HPH-1 Protein, HIF prolyl hydroxylase 3 Protein, HIF-prolyl hydroxylase 3 Protein, HIFPH3 Protein, PHD3 Protein, EGL nine (C.elegans) homolog 3 Protein, Egl nine homolog 3 Protein, HIF-PH3 Protein, HIFP4H3 Protein

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site.

Requested From: United States
Date Requested: 12/11/2016

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