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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Human Basigin / Emmprin / CD147 Protein (Recombinant His) - LS-G5239
21.6 kDa. DTT-reduced protein migrates as 26-33 kDa due to glycosylation
HEK 293 Cells
Human
His
Greater than 95% by SDS-PAGE
Measured by the ability of the immobilized protein to induce active MMP1 secretion by NHLF human normal lung fibroblasts. The ED50 for this effect is typically 0.5-4 µg/ml.
Less than 1.0 EU/µg protein (determined by LAL method).
Lyophilized from PBS, pH 7.4, mannitol or trehalose
Centrifuge the vial before opening. Reconstitute in sterile PBS, pH 7.4 to 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, store at -20°C.
BSG Protein, 5F7 Protein, Basigin Protein, Basigin (Ok blood group) Protein, CD147 antigen Protein, Collagenase stimulatory factor Protein, EMMPRIN Protein, OK Protein, OK blood group antigen Protein, TCSF Protein, CD147 Protein, M6 Protein
Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
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