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Human BAFF Recombinant (Human IgG1 Fc) Protein LS-G3957

Ordering

Wt. Vol. Conc. Price
10 µg - - $355
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular BAFF Proteins

Human BAFF Recombinant Protein - LS-G4434
E. coli Expression System
None
Unpurified / Endotoxin Level: Less than 0.1 ng/µg of protein.
Rat BAFF Recombinant Protein - LS-G4440
E. coli Expression System
None
Unpurified / Endotoxin Level: Less than 0.1 ng/µg of protein.
Human BAFF Recombinant Protein - LS-G16806
E. coli Expression System
None
Unpurified

100% Guaranteed 100% Guaranteed
LS-G3957
Recombinant Protein
BAFF
Human
~50kDa (SDS-PAGE; reducing conditions)~100kDa (SDS-PAGE; non-reducing conditions)~300kDa (SDS-PAGE; native conditions; multimerizes and forms hexamers)
The receptor-binding domain of human BAFF (aa 136-285) is fused at the N-terminus to the Fc portion of human IgG1.
aa 136-285
CHO Cells
Hamster-Chinese
Human IgG1 Fc
Greater than 95% by SDS-PAGE
Rescues the production of mature follicular and marginal zone B cells. - in vitro: Addition of 1-100 ng/ml of Fc-BAFF induces B cell survival in a dose-dependent manner. - in vivo: Fc-BAFF treatment rescues mature B cell development in BAFF deficient mice
Less than 0.01 EU/µg protein (determined by LAL method).
Lyophilized from PBS.
Reconstitute with 100 µl sterile water.
Store lyophilized at -20°C for at least 6 months. Once reconstituted store at +4°C for immediate use.
For research use only.

About BAFF

Q9Y275 NM_006573 NP_006564.1

TNFSF13B Protein, B-cell-activating factor Protein, BAFF Protein, ApoL related ligand TALL-1 Protein, B-lymphocyte stimulator Protein, CD257 Protein, BLYS Protein, Delta4 BAFF Protein, Delta BAFF Protein, TALL-1 Protein, TALL1 Protein, ZTNF4 Protein, THANK Protein, B lymphocyte stimulator Protein, CD257 antigen Protein, TNFSF20 Protein

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase).

Functional Assay

Functional Assay
Restoration of the splenic T and B cell architecture in Fc-BAFF injected BAFFdeficient mice. BAFF deficient mice were injected at day 0 with 100mg BAFF (human):Fc (human) (AG-40B-0120) intravenously and at day 14 with 50mg BAFF (human):Fc (human) intraperitoneal. At day 21, injected BAFFdeficient mice were sacrificed together with WT and control BAFFdeficient mice and splenic T and B cell architecture was analyzed by fluorescence microscopy on cryosections. A, Spleen sections of WT (left picture), BAFF deficient (middle picture) or injected BAFFdeficient mice (right picture) were stained for IgM (red) and CD90 (green). (B) Spleen sections of the same mice were stained for IgM (green) and MOMA (red).
 

Requested From: United States
Date Requested: 12/7/2016

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