Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ANGPTL3 Protein, ANGPT5 Protein, ANG-5 Protein, Angiopoietin-5 Protein, Angiopoietin-like 3 Protein, Angiopoietin-related protein 3 Protein, FHBL2 Protein, Angiopoietin 5 Protein, Angiopoietin-like protein 3 Protein
ANGPTL3 encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
ERK phosphorylation induced by hANGPTL3 in THP-1 cells. THP-1 monocyte cells were serum starved for 16 hours and then stimulated with ANGPTL3 (human) (rec.) (500ng/ml) for 1, 2 and 3 hours, respectively. Antibodies against pERK1/2 and total ERK1/2 were used for immunoblotting.