Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Purified / Lyophilized / Endotoxin Level: Less than 1.0 EU/µg protein (determined by LAL method).
KLRK1 / CD314 / NKG2D
Greater than 95% by SDS-PAGE
1. Immobilized Rhesus His-NKG2D (78-216) at 10 µg/ml (100 µl/well) can bind human ULBP1-Fch, The EC50 of human ULBP1-Fch is 0.12-0.28 µg/ml. 2. Immobilized Rhesus His-NKG2D (78-216) at 10 µg/ml (100 µl/well) can bind human MICB-Fch, The EC50 of human MICB-Fch is 33.8-79 ng/ml.
Less than 1.0 EU/µg protein (determined by LAL method).
Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.01.
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
KLRK1 Protein, D12S2489E Protein, CD314 antigen Protein, KLR Protein, NK cell receptor D Protein, NKG2D Protein, NKG2-D Protein, NKG2-D-activating NK receptor Protein, CD314 Protein
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.