Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Measured by its ability to inhibit recombinant human BMP4 induced alkaline phosphatase production by MC3T3-E1 cells. The ED50 for this effect is typically 1-7 µg/mL in the presence of 50 ng/mL of recombinant human BMP4.
Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol, 0.5 mM EDTA, 3 mM DTT.
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
GREM1 Protein, CKTSF1B1 Protein, DAN domain family member 2 Protein, DAND2 Protein, DRM Protein, GREMLIN Protein, Gremlin 1-like protein Protein, Increased in high glucose-2 Protein, Gremlin-1 Protein, PIG2 Protein, Proliferation-inducing gene 2 Protein, Gremlin 1 Protein, IHG-2 Protein
GREM1 / Gremlin-1 is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins.