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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-B7044-50 50 µl (1 mg/ml) $425 
MCM2 Antibody - Anti-MCM2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
MCM2 Antibody - Immunofluorescence analysis of HepG2 cells, using MCM2 Antibody. The picture on the right is blocked with the synthesized peptide.
MCM2 Antibody - Western blot analysis of lysates from 293 cells, using MCM2 Antibody. The lane on the right is blocked with the synthesized peptide.
MCM2 Antibody - Anti-MCM2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
MCM2 Antibody - Immunofluorescence analysis of HepG2 cells, using MCM2 Antibody. The picture on the right is blocked with the synthesized peptide.
MCM2 Antibody - Western blot analysis of lysates from 293 cells, using MCM2 Antibody. The lane on the right is blocked with the synthesized peptide.
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PathPlus™ Polyclonal Rabbit anti‑Human MCM2 Antibody (aa1‑50, IHC, IF, WB) LS‑B7044

PathPlus™ Polyclonal Rabbit anti‑Human MCM2 Antibody (aa1‑50, IHC, IF, WB) LS‑B7044

Note: This antibody replaces LS-C118514
Antibody:
Rabbit Polyclonal to Human MCM2
Application:
IHC, IHC-P, IF, WB, Peptide-ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B7044-50
50 µl
1 mg/ml
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human MCM2
Application:
IHC, IHC-P, IF, WB, Peptide-ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified

Specifications

Description
MCM2 is a component of the MCM complex, a replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. MCM2 is required for entry into the S phase and for cell division. MCM2 is a useful marker in immunohistochemistry for characterizing a number of cancers. It is overexpressed in precancerous and cancerous cervical lesions and upregulation is associated with high-risk type HPV. In squamous cell and adenocarcinoma of the gallbladder, MCM2 positivity is associated with metastasis and poor prognosis. It has similar prognostic value in oral dysplasia and ovarian serous neoplasms, where expression increases with severity of tumor grade. In immunohistochemistry of normal tissue, MCM2 has nuclear positivity in proliferative cells throughout the body. References: Int J Clin Exp Pathol. 2015; 8(1): 875–880, PMID: 25755789; Mol Med Rep. 2016 Nov; 14(5): 4581–4592, PMID: 27748889; Applied Immunohistochemistry & Molecular Morphology. 2018 Aug. 26(7):509–513, DOI: 10.1097/PAI.0000000000000330; British Journal of Cancer. 2004. 90:1583–1590, PMID: 15083189
Target
Human MCM2
Synonyms
MCM2 | BM28 | Cell devision cycle-like 1 | D3S3194 | Cdc19 | Cyclin-like 1 | KIAA0030 | Nuclear protein BM28 | CDCL1 | MITOTIN
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:100)
  • Immunofluorescence (1:100 - 1:500)
  • Western blot (1:500 - 1:1000)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:40000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide from human MCM2. (AA Range: 1-50)
Epitope
aa1-50
Specificity
MCM2 Antibody detects endogenous levels of total MCM2 protein.
Usage
Western Blot: Predicted MW 101 kDa
Presentation
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide, 50% Glycerol
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About MCM2
P49736 NM_004526 NP_004517.2

Validation

MCM2 Antibody - Anti-MCM2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-MCM2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-MCM2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

LSBio Ratings

PathPlus™ MCM2 Antibody (aa1-50) for IHC, IF/Immunofluorescence, WB/Western LS-B7044 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 6/5/2020