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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
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866-819-4732 (Toll Free North America
206-374-1102 (International)
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PathPlusTM ACP5 / TRAP Antibodies
ACP5 (Acid phosphatase 5, Tartrate-resistant acid phosphatase, TRAP) is an iron-containing glycoprotein that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. Broadly, it functions in skeletal development, bone mineralization, collagen synthesis and degradation, as well as dendritic cell maturation and macrophage recruitment. ACP5 is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. It is expressed at high levels by osteoclasts, macrophages and dendritic cells. Two forms circulating in human blood (designated 5a and 5b) are derived from different cell types and have different functions. 5a is derived from macrophages and dendritic cells and is a marker of inflammatory conditions. 5b is derived from osteoclasts and is a marker of bone resorption. It is believed to initiate osteoclast differentiation and proliferation, and is capable of degrading skeletal phosphoproteins such as osteopontin. Separately, ACP5 is thought to function in hyperplastic obesity, and is associated with morbid obesity in mice when overexpressed. In immunohistochemistry, ACP5 has membranous staining. It is a useful positive marker for B lymphocytes of the marginal zone and osteoclasts in normal tissue, and for a range of cancers including hairy cell leukemia, mantle cell lymphoma, primary mediastinal B cell lymphoma, and some splenic marginal zone lymphomas. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Autoimmunity. 2008. 41(3), DOI: 10.1080/08916930701694667; Biomarkers. 2017. 22 (8), DOI: 10.1080/1354750X.2017.1334155; Hum Pathol 2005;36:945, PMID: 16153456;

2 PathPlusTM Antibodies
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ACP5 / TRAP Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
Mouse Monoclonal [clone 5C5E7] (IgG1) to Human ACP5 / TRAP
Human
ELISA, Flo, IHC-P, WB
Unconjugated
100µl   1mg/ml   $485.00
ACP5 / TRAP Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
Mouse Monoclonal [clone 26E5] (IgG2b) to Human ACP5 / TRAP
Human
IHC, IHC-P
Unconjugated
50µl   $425.00

Viewing 1-2 of 2 items