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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
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866-819-4732 (Toll Free North America
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PathPlusTM ABCA7 Antibodies
ABCA7 is an ATP-binding cassette transporter that carries various molecules across extra- and intra-cellular membranes. This protein has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. ABCA7 is involved in ovarian cancer progression, as it has been found to upregulate the TGF-beta signaling pathway resulting in an accelerated epithelial-to-mesenchymal transition. Knockdown of ABCA7 has been shown to decrease the migration of ovarian cancer cells. In immunohistochemistry of normal tissue, ABCA7 has cytoplasmic and membranous positivity in the brain, bone marrow, lymph nodes, spleen, and thymus, and in leukocytes and immune cells in tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Oncol Lett. 2018 Nov;16(5):5868-5874, PMID: 30333865

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ABCA7 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
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Rabbit Polyclonal to Human ABCA7
IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00

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