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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
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866-819-4732 (Toll Free North America
206-374-1102 (International)
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PathPlusTM ABCA1 Antibodies
ABCA1 (ATP-binding cassette subfamily A member 1, CERP) is a transporter protein that modulates phospholipid homeostasis, cellular cholesterol. ABCA1 is necessary for proper cholesterol metabolism and transport in the central nervous system. It has highest expression in the liver, adipose tissue and the small intestine, and is otherwise found throughout the body. Mutations in ABCA1 lead to the rare Tangier’s disease, described by a massive reduction in high density lipoprotein in the body and which can lead to neuropathy and cardiovascular disease. Downregulation of ABCA1 leads to atherogenesis through a disruption of cholesterol transport within cells and is a factor in the pathogenesis of atherosclerosis and macular degeneration. Upregulation of ABCA1 has been found to reduce amyloid deposition in mouse models of Alzheimer’s disease. In immunohistochemistry of normal tissue, ABCA1 has membranous and cytoplasmic positivity in tissues throughout the body. References: Cell Metabolism. 17 (4): 549–61, PMID: 23562078; J Clin Invest. 2008;118(2):671–682, DOI: doi.org/10.1172/JCI33622; J Neurosci. 2009 Mar 18; 29(11): 3579–3589, PMID: 19295162

2 PathPlusTM Antibodies
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ABCA1 Antibody - Anti-ABCA1 antibody IHC of human colon, ganglion cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroscience
Rabbit Polyclonal to Human ABCA1
Chicken, Mouse, Dog, Rat, Hamster, Pig, Mustelid, Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $425.00
ABCA1 Antibody - Anti-ABCA1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Neuroscience
Rabbit Polyclonal (IgG) to Human ABCA1
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00

Viewing 1-2 of 2 items