Human TLE1 / TLE 1
TLE1 | E(Sp1) homolog | ESG | GRG1 | Enhancer of split groucho 1 | ESG1
(tested or 100% immunogen sequence identity)
Also available Azide-free, Carrier-free
Recombinant human TLE1 fragment (aa 175-338). Antigen Molecular Weight: 83 kDa
Key players in the Notch pathway are the TLE genes, which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. Transducin-like enhancer protein 1 (TLE1) is a protein that is encoded by the TLE1 gene and is involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation. Positive immunohistochemical nuclear staining with anti-TLE-1 has been shown to be a useful addition to an IHC panel when differentiating synovial sarcoma from other soft tissue malignancies.