PROKR2 is a receptor for prokineticin 2. It is exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation of this receptor leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Mutations in this gene lead to hypogonadotropic hypogonadism and gynecomastia. It differentially expressed in colorectal cancer, where it is thought to be involved in invasion and progression into peritoneal carcinomatosis via dysregulation of the EG-VEGF/PROKR system. In immunohistochemistry of normal tissue, PROKR2 has membranous positivity in the cerebral cortex and at lower levels throughout the central nervous system, and is also found in some peripheral and immune tissues. References: Cancer Biomark. 2018 Feb 6;21(2):345-354, PMID: 29226856