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Catalog Number Size Price
LS-A5738-50 50 µg (1 mg/ml) $460 
NR6A1 / GCNF Antibody - Ovary, carcinoma
NR6A1 / GCNF Antibody - Skin, Melanoma
NR6A1 / GCNF Antibody - Anti-NR6A1 / GCNF antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NR6A1 / GCNF Antibody - Lung, Non Small-Cell Carcinoma
NR6A1 / GCNF Antibody - Ovary, carcinoma
NR6A1 / GCNF Antibody - Skin, Melanoma
NR6A1 / GCNF Antibody - Anti-NR6A1 / GCNF antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NR6A1 / GCNF Antibody - Lung, Non Small-Cell Carcinoma
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PathPlus™ Polyclonal Rabbit anti‑Human NR6A1 / GCNF Antibody (Ligand‑binding Domain, IHC) LS‑A5738

PathPlus™ Polyclonal Rabbit anti‑Human NR6A1 / GCNF Antibody (Ligand‑binding Domain, IHC) LS‑A5738

Antibody:
NR6A1 / GCNF Rabbit anti-Human Polyclonal (Ligand-binding Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Chicken
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A5738-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
NR6A1 / GCNF Rabbit anti-Human Polyclonal (Ligand-binding Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Chicken
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Germ cell nuclear factor (GCNF), a NR6 Germ Cell Nuclear Factor-Like Receptor, has been shown to affect gene expression in embryogenesis and spermatogenesis and is essential for embryonic survival and normal development. Loss of GCNF causes embryonic lethality and disrupts normal somitogenesis as well as neural-tube and axis formation. GCNF binds as a homodimer to the DR0 DNA response element and has been shown to regulate transcription of genes including protamines1 and 2 and Oct4. GCNF's repression function has been shown to be mediated by interaction with the co-repressors N-COR and SMRT in the absence of ligand. Three protein isoforms, GCNF-1, GCNF-2a, and GCNF-2b, have been documented in humans, and they are generated by differential usage of alternative splice acceptor sites of the fourth and seventh exons. GCNF-1, the longest isoform, has a distinct 5' UTR and contains 4 and 26 additional amino acids than the other two forms, respectively. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human NR6A1 / GCNF
Synonyms
NR6A1 | Germ cell nuclear factor | HGCNF | NR61 | HRTR | RTR | Ncnf | GCNF | GCNF1
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Chicken (tested or 100% immunogen sequence identity)
Predicted
Zebrafish (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 18 amino acid peptide from ligand-binding domain of human NR6A1 / GCNF. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig, Turkey, Chicken, Platypus (100%); Stickleback, Pufferfish, Zebrafish (94%); Xenopus (89%).
Epitope
Ligand-binding Domain
Specificity
Human NR6A1 / GCNF. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (4 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About NR6A1 / GCNF
Q15406 NM_033334 NP_201591.2

Validation

NR6A1 / GCNF Antibody - Ovary, carcinoma
Ovary, carcinoma
Ovary, carcinoma

NR6A1 / GCNF Antibody - Skin, Melanoma
Skin, Melanoma
Skin, Melanoma

NR6A1 / GCNF Antibody - Anti-NR6A1 / GCNF antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR6A1 / GCNF antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR6A1 / GCNF antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

NR6A1 / GCNF Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

LSBio Ratings

PathPlus™ NR6A1 / GCNF Antibody (Ligand-binding Domain) for IHC LS-A5738 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/16/2021