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Catalog Number Size Price
LS-B10207-50 50 µl $485 
INSR / Insulin Receptor Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
INSR / Insulin Receptor Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
INSR / Insulin Receptor Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
INSR / Insulin Receptor Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
INSR / Insulin Receptor Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
INSR / Insulin Receptor Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PathPlus™ Monoclonal Mouse anti‑Human INSR / Insulin Receptor Antibody (clone 83‑7, Azide‑free, IHC) LS‑B10207

PathPlus™ Monoclonal Mouse anti‑Human INSR / Insulin Receptor Antibody (clone 83‑7, Azide‑free, IHC) LS‑B10207

Note: This antibody replaces LS-C88307
Antibody:
INSR / Insulin Receptor Mouse anti-Human Monoclonal (Azide-free) (83-7) Antibody
Application:
IHC-P, Flo, ELISA
Reactivity:
Human, Bovine, Pig, Rabbit, Sheep
Format:
Unconjugated, Azide-free
Price
Catalog Number
$485
LS-B10207-50
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
INSR / Insulin Receptor Mouse anti-Human Monoclonal (Azide-free) (83-7) Antibody
Application:
IHC-P, Flo, ELISA
Reactivity:
Human, Bovine, Pig, Rabbit, Sheep
Format:
Unconjugated, Azide-free

Specifications

Description
INSR (Insulin receptor, CD22) is a receptor tyrosine kinase that is pivotal to the regulation of glucose homeostasis and mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Phosphorylation of IRS proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Pathogenic variants in INSR are associated with severe syndromic insulin resistance including the diseases Donohue syndrome and Rabson-Mendenhall syndrome and for increased risk of gestational diabetes. In immunohistochemistry, INSR has cytoplasmic positivity in all tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Ben harouch S, Klar A, Falik Zaccai TC. INSR-Related Severe Syndromic Insulin Resistance. GeneReviews. Seattle (WA): University of Washington, Seattle. 2018. URL: https://www.ncbi.nlm.nih.gov/books/NBK476444/;
Target
Human INSR / Insulin Receptor
Synonyms
INSR | CD220 | ILP receptor | Insulin receptor | IR | HHF5 | CD220 antigen
Host
Mouse
Reactivity
Human, Bovine, Pig, Rabbit, Sheep (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Clone
83-7
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Azide-free
Immunogen
IM-9 lymphocytes followed by IR.
Specificity
Human insulin receptor alpha subunit (exon 3).
Applications
  • IHC - Paraffin (10 µg/ml)
  • Flow Cytometry
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Presentation
10 mM PBS, pH 7.4
Storage
Stable for 36 months when stored at or below 0°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About INSR / Insulin Receptor
P06213 NM_000208 NP_000199.2

Validation

INSR / Insulin Receptor Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

INSR / Insulin Receptor Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

INSR / Insulin Receptor Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ INSR / Insulin Receptor Antibody (clone 83-7, Azide-free) for IHC, Flow, ELISA LS-B10207 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/27/2021