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Catalog Number Size Price
LS-A5162-50 50 µg (1 mg/ml) $440 
HNF4G / HNF4 Gamma Antibody - Breast carcinoma
HNF4G / HNF4 Gamma Antibody - Lung, Non Small-Cell Carcinoma
HNF4G / HNF4 Gamma Antibody - Pancreas, carcinoma
HNF4G / HNF4 Gamma Antibody - Brain, Glioblastoma
HNF4G / HNF4 Gamma Antibody - Breast, Carcinoma
HNF4G / HNF4 Gamma Antibody - Pancreas, Carcinoma
HNF4G / HNF4 Gamma Antibody - Anti-HNF4G antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
HNF4G / HNF4 Gamma Antibody - Breast carcinoma
HNF4G / HNF4 Gamma Antibody - Lung, Non Small-Cell Carcinoma
HNF4G / HNF4 Gamma Antibody - Pancreas, carcinoma
HNF4G / HNF4 Gamma Antibody - Brain, Glioblastoma
HNF4G / HNF4 Gamma Antibody - Breast, Carcinoma
HNF4G / HNF4 Gamma Antibody - Pancreas, Carcinoma
HNF4G / HNF4 Gamma Antibody - Anti-HNF4G antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human HNF4G / HNF4 Gamma Antibody (Internal, IHC) LS‑A5162

PathPlus™ Polyclonal Rabbit anti‑Human HNF4G / HNF4 Gamma Antibody (Internal, IHC) LS‑A5162

Note: This antibody replaces LS-C67683
Antibody:
HNF4G / HNF4 Gamma Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$440
LS-A5162-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
HNF4G / HNF4 Gamma Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
HNF4G (Hepatocyte nuclear factor 4 gamma) is a NR2 Hepatocyte NF4-Like receptor. HNF4G is a pioneer factor that regulates a transcriptome of gastrointestinal lineage genes. Knockout studies have also revealed that it is involved in regulating energy expenditure, locomotor activity and food intake. It is structurally similar to HNF4 alpha and they are co-expressed in pancreatic islets. It is upregulated in some cancers, including bladder, prostate and lung cancer. In a small subclass of prostate cancers, the gastrointestinal regulatory profile of HNF4G is co-opted by tumor cells as part of therapy resistance. In lung cancers that overexpress HNF4G, expression correlates with tumor size and poor prognosis and it is thought to promote tumor cell proliferation. In immunohistochemistry, HNF4G has selective nuclear positivity in small intestine, and potentially also in the pancreas, liver, gallbladder kidney, and testis. References: Oncotarget. 2018 Apr 6; 9(26): 18018–18028, PMID: 29719587; Cancer Cell. 2017 Dec 11;32(6):792-806.e7, PMID: 29153843
Target
Human HNF4G / HNF4 Gamma
Synonyms
HNF4G | HNF-4-gamma | HNF4-beta | HNF4 gamma | Hnf4gamma | NR2A3 | NR2A2
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey, Mouse, Dog (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from internal region of human HNF4G. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Mouse, Elephant, Panda, Dog (94%); Bat, Horse, Turkey, Chicken (88%); Rat, Pig, Opossum, Platypus (81%).
Epitope
Internal
Specificity
Human HNF4G. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except HNF4A (63%).
Applications
  • IHC
  • IHC - Paraffin (16 - 32 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About HNF4G / HNF4 Gamma
Q14541 NM_004133 AAI05012.1

Validation

HNF4G / HNF4 Gamma Antibody - Breast carcinoma
Breast carcinoma
Breast carcinoma

HNF4G / HNF4 Gamma Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

HNF4G / HNF4 Gamma Antibody - Pancreas, carcinoma
Pancreas, carcinoma
Pancreas, carcinoma

HNF4G / HNF4 Gamma Antibody - Brain, Glioblastoma
Brain, Glioblastoma
Brain, Glioblastoma

HNF4G / HNF4 Gamma Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

HNF4G / HNF4 Gamma Antibody - Pancreas, Carcinoma
Pancreas, Carcinoma
Pancreas, Carcinoma

HNF4G / HNF4 Gamma Antibody - Anti-HNF4G antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HNF4G antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HNF4G antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ HNF4G / HNF4 Gamma Antibody (Internal) for IHC LS-A5162 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/28/2021