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Catalog Number Size Price
LS-A1273-50 50 µg (1 mg/ml) $460 
GPR45 Antibody - Lung, non small cell carcinoma
GPR45 Antibody - Ovary, Carcinoma
GPR45 Antibody - Brain, substantia nigra
GPR45 Antibody - Anti-GPR45 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR45 Antibody - Anti-GPR45 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR45 Antibody - Anti-GPR45 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR45 Antibody - Anti-GPR45 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR45 Antibody - Anti-GPR45 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR45.
GPR45 Antibody - Lung, non small cell carcinoma
GPR45 Antibody - Ovary, Carcinoma
GPR45 Antibody - Brain, substantia nigra
GPR45 Antibody - Anti-GPR45 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR45 Antibody - Anti-GPR45 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR45 Antibody - Anti-GPR45 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR45 Antibody - Anti-GPR45 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR45 Antibody - Anti-GPR45 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR45.
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PathPlus™ Polyclonal Rabbit anti‑Human GPR45 Antibody (Cytoplasmic Domain, IHC) LS‑A1273

PathPlus™ Polyclonal Rabbit anti‑Human GPR45 Antibody (Cytoplasmic Domain, IHC) LS‑A1273

Antibody:
GPR45 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P, ICC
Reactivity:
Human, Monkey, Horse
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A1273-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
GPR45 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P, ICC
Reactivity:
Human, Monkey, Horse
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
G protein-coupled receptor 45 (GPR45) is a transmembrane receptor that mediates signaling processes to the interior of the cell via activation of heterotrimeric G proteins. GPR45 functions in the central nervous system, and it is thought to regulate energy expenditure and POMC signaling. Mutations in GPR45 can lead to obesity, and this receptor may be target of interest in obesity therapies. In immunohistochemistry, GPR45 has membranous positivity on neurons in the substantia nigra and nucleus basalis of Meynert in the brain, and has faint positivity on astrocytes in the amygdala and Bergman glia. Scattered positivity on neurons is also seen in other regions in the brain. Outside of the nervous system, genitourinary epithelial cells in the kidney and bladder express GPR45, and it is also present in adipocytes and has faint positivity in epithelial tissues. In cancer, GPR45 is expressed on neoplastic cells in glioblastoma multiforme, malignant melanoma, and breast, lung, and ovarian adenocarcinomas. References: J Clin Invest. 2016 Sep 1;126(9):3192-206, PMID: 27500489;
Target
Human GPR45
Synonyms
GPR45 | G protein-coupled receptor 45 | PSP24(ALPHA) | PSP24-1 | PSP24 | PSP24A | PSP24-alpha
Host
Rabbit
Reactivity
Human, Monkey, Horse (tested or 100% immunogen sequence identity)
Predicted
Mouse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human GPR45. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Horse (100%); Mouse, Panda (94%); Rabbit (88%); Rat, Bat (81%).
Epitope
Cytoplasmic Domain
Specificity
Human GPR45. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (42 µg/ml)
  • ICC
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GPR45
Q9Y5Y3 NM_007227 NP_009158.3

Validation

GPR45 Antibody - Lung, non small cell carcinoma
Lung, non small cell carcinoma
Lung, non small cell carcinoma

GPR45 Antibody - Ovary, Carcinoma
Ovary, Carcinoma
Ovary, Carcinoma

GPR45 Antibody - Brain, substantia nigra
Brain, substantia nigra
Brain, substantia nigra

GPR45 Antibody - Anti-GPR45 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR45 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR45 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR45 Antibody - Anti-GPR45 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR45 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR45 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR45 Antibody - Anti-GPR45 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR45 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR45 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR45 Antibody - Anti-GPR45 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR45 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR45 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR45 Antibody - Anti-GPR45 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR45.
Anti-GPR45 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR45.
Anti-GPR45 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR45.

LSBio Ratings

PathPlus™ GPR45 Antibody (Cytoplasmic Domain) for IHC, ICC LS-A1273 has an LSBio Rating of
Laboratory Validation Score (5)

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Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/27/2021