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Catalog Number Size Price
LS-A331-50 50 µg (1 mg/ml) $460 
GPR161 Antibody - Anti-GPR161 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR161 Antibody - Brain, Pituitary, pars anterior
GPR161 Antibody - Anti-GPR161 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR161 Antibody - Anti-GPR161 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR161 Antibody - Anti-GPR161 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR161 Antibody - Anti-GPR161 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR161.
GPR161 Antibody - Anti-GPR161 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
GPR161 Antibody - Anti-GPR161 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR161.
GPR161 Antibody - Anti-GPR161 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
GPR161 Antibody - Anti-GPR161 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR161 Antibody - Brain, Pituitary, pars anterior
GPR161 Antibody - Anti-GPR161 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR161 Antibody - Anti-GPR161 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR161 Antibody - Anti-GPR161 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR161 Antibody - Anti-GPR161 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR161.
GPR161 Antibody - Anti-GPR161 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
GPR161 Antibody - Anti-GPR161 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR161.
GPR161 Antibody - Anti-GPR161 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
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PathPlus™ Polyclonal Rabbit anti‑Human GPR161 Antibody (N‑Terminus, IHC) LS‑A331

PathPlus™ Polyclonal Rabbit anti‑Human GPR161 Antibody (N‑Terminus, IHC) LS‑A331

Antibody:
GPR161 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, ICC
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A331-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
GPR161 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, ICC
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
G protein-coupled receptor 161 (GPR161) is a key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. GPR161, in presence of SHH, is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. It has also been reported to regulate forelimb formation and skeletal morphogenesis. References: Development 2018 145: dev154054 doi: 10.1242/dev.154054 Published 8 January 2018
Target
Human GPR161
Synonyms
GPR161 | G-protein coupled receptor 161 | G protein-coupled receptor 161 | G-protein coupled receptor RE2 | RE2
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 18 amino acid peptide from N-Terminus extracellular domain of human GPR161. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset (94%); Horse (89%); Hamster, Dog, Rabbit, Pig (83%).
Epitope
N-Terminus
Specificity
Human GPR161. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (4 - 9 µg/ml)
  • ICC
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GPR161
Q8N6U8 NM_007369 NP_722561.1

Validation

GPR161 Antibody - Anti-GPR161 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR161 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR161 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR161 Antibody - Brain, Pituitary, pars anterior
Brain, Pituitary, pars anterior
Brain, Pituitary, pars anterior

GPR161 Antibody - Anti-GPR161 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR161 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR161 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR161 Antibody - Anti-GPR161 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR161 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR161 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR161 Antibody - Anti-GPR161 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR161 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR161 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR161 Antibody - Anti-GPR161 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR161.
Anti-GPR161 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR161.
Anti-GPR161 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with GPR161.

GPR161 Antibody - Anti-GPR161 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
Anti-GPR161 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
Anti-GPR161 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.

LSBio Ratings

PathPlus™ GPR161 Antibody (N-Terminus) for IHC, ICC LS-A331 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/27/2021