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Catalog Number Size Price
LS-B15150-50 50 µg $460 
GLS / Glutaminase Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

PathPlus™ Polyclonal Rabbit anti‑Human GLS / Glutaminase Antibody (IHC) LS‑B15150

PathPlus™ Polyclonal Rabbit anti‑Human GLS / Glutaminase Antibody (IHC) LS‑B15150

Note: This antibody replaces LS-C395751
Antibody:
GLS / Glutaminase Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-B15150-50
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
GLS / Glutaminase Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
GLS (Glutaminase) is the K-type mitochondrial glutaminase, a phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in axonal terminals of neurons in the brain and in periportal hepatocytes and renal tubules in the kidney. It plays a pivotal role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and in maintaining acid-base balance in the kidney. As numerous cancers use glutamate for metabolic and proliferative processes, GLS inhibitors are of interest as potential cancer treatments. In immunohistochemistry, GLS has highest granular cytoplasmic positivity in the brain and kidney, and is also found in the thyroid, lung, gastrointestinal tract, liver, pancreas, reproductive tissues and muscle. References: International Journal of Molecular Sciences. 16 (9): 22830–55, PMID: 26402672; Kidney Cancer. 2019 Feb 5;3(1):15-29, PMID: 30854496;
Target
Human GLS / Glutaminase
Synonyms
GLS | AAD20 | GLS1 | GAM | Glutaminase C | GAC | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase | Glutaminase | KGA
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with HRP, FITC, Biotin.
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Recombinant human Glutaminase kidney isoform, mitochondrial protein.
Specificity
Human GLS / Glutaminase
Applications
  • IHC
  • IHC - Paraffin (1:100 - 1:200)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GLS / Glutaminase
O94925 NM_014905 NP_055720.3

Validation

GLS / Glutaminase Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ GLS / Glutaminase Antibody for IHC, ELISA LS-B15150 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 6/25/2024