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Catalog Number Size Price
LS-A1310-50 50 µg (1 mg/ml) $460 
F2RL3 / PAR4 Antibody - Colon, Carcinoma
F2RL3 / PAR4 Antibody - Ovary, carcinoma
F2RL3 / PAR4 Antibody - Skin, Malignant Melanoma
F2RL3 / PAR4 Antibody - Breast, Carcinoma
F2RL3 / PAR4 Antibody - Anti-F2RL3 / PAR4 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
F2RL3 / PAR4 Antibody - Ovary, Carcinoma
F2RL3 / PAR4 Antibody - Anti-F2RL3 / PAR4 antibody IHC of human bone marrow. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
F2RL3 / PAR4 Antibody - Colon, Carcinoma
F2RL3 / PAR4 Antibody - Ovary, carcinoma
F2RL3 / PAR4 Antibody - Skin, Malignant Melanoma
F2RL3 / PAR4 Antibody - Breast, Carcinoma
F2RL3 / PAR4 Antibody - Anti-F2RL3 / PAR4 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
F2RL3 / PAR4 Antibody - Ovary, Carcinoma
F2RL3 / PAR4 Antibody - Anti-F2RL3 / PAR4 antibody IHC of human bone marrow. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human F2RL3 / PAR4 Antibody (Extracellular Domain, IHC) LS‑A1310

PathPlus™ Polyclonal Rabbit anti‑Human F2RL3 / PAR4 Antibody (Extracellular Domain, IHC) LS‑A1310

Antibody:
F2RL3 / PAR4 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A1310-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
F2RL3 / PAR4 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
F2RL3 (Proteinase-Activated Receptor 4, PAR4) is a member of the Proteinase-Activated Receptor subfamily and is activated by trypsin and thrombin. Binding by thrombin leads to the activation of platelets, leukocytes, endothelial cells and mesenchymal cells at sites of vascular injury. These cellular responses are triggered through proteolytic activation of the receptors by thrombin. It is believed that F2RL3 functions as a cofactor for the cleavage and activation of F2RL3. In clear cell renal cell carcinoma, high expression of F2RL3 is associated with poor prognosis and aggressive characteristics. In immunohistochemistry, F2RL3 has membranous positivity in Herring bodies of the posterior pituitary, Bergmann glia of the cerebellum and variable staining in neurons of the CA2 hippocampus, lateral hypothalamic nucleus and basal nucleus of Meynert in the brain. In peripheral tissues, it has moderate to strong positivity in hepatocytes, the bronchial respiratory epithelium, pancreatic exocrine cells, neuroendocrine cells of the small intestine, the placenta, the urinary bladder, sweat glands, the thymus, and also on neutrophils in some tissues including the anterior pituitary and spleen. References: J Cancer. 2018; 9(18): 3400–3406, PMID: 30271502
Target
Human F2RL3 / PAR4
Synonyms
F2RL3 | PAR4 | Thrombin receptor-like 3 | Par-4 | Protease-activated receptor-4
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from 2nd extracellular domain of human F2RL3 / PAR4. Percent identity with other species by BLAST analysis: Human, Monkey (100%); Gorilla, Gibbon (94%); Marmoset, Mouse, Dog, Bovine, Panda (81%).
Epitope
Extracellular Domain
Specificity
Human F2RL3 / PAR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (2 - 5 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About F2RL3 / PAR4
Q96RI0 NM_003950 NP_003941.2

Validation

F2RL3 / PAR4 Antibody - Colon, Carcinoma
Colon, Carcinoma
Colon, Carcinoma

F2RL3 / PAR4 Antibody - Ovary, carcinoma
Ovary, carcinoma
Ovary, carcinoma

F2RL3 / PAR4 Antibody - Skin, Malignant Melanoma
Skin, Malignant Melanoma
Skin, Malignant Melanoma

F2RL3 / PAR4 Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

F2RL3 / PAR4 Antibody - Anti-F2RL3 / PAR4 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2RL3 / PAR4 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2RL3 / PAR4 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

F2RL3 / PAR4 Antibody - Ovary, Carcinoma
Ovary, Carcinoma
Ovary, Carcinoma

F2RL3 / PAR4 Antibody - Anti-F2RL3 / PAR4 antibody IHC of human bone marrow. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2RL3 / PAR4 antibody IHC of human bone marrow. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2RL3 / PAR4 antibody IHC of human bone marrow. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ F2RL3 / PAR4 Antibody (Extracellular Domain) for IHC LS-A1310 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/17/2021