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Catalog Number Size Price
LS-A3570-50 50 µg (0.71 mg/ml) $440 
CRHR2 / CRF2 Receptor Antibody
CRHR2 / CRF2 Receptor Antibody - Anti-CRHR2 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CRHR2 / CRF2 Receptor Antibody
CRHR2 / CRF2 Receptor Antibody - Anti-CRHR2 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human CRHR2 / CRF2 Receptor Antibody (N‑Terminus, IHC) LS‑A3570

PathPlus™ Polyclonal Rabbit anti‑Human CRHR2 / CRF2 Receptor Antibody (N‑Terminus, IHC) LS‑A3570

Antibody:
CRHR2 / CRF2 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bovine, Rabbit
Format:
Unconjugated, Unmodified
Price
Catalog Number
$440
LS-A3570-50

Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
CRHR2 / CRF2 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bovine, Rabbit
Format:
Unconjugated, Unmodified

Specifications

Description
CRHR2 (Corticotropin-releasing hormone receptor 2) is a protein of the G-protein coupled receptor 2 family that binds corticotropin-releasing hormone (CRH) and CRH-related peptides such as urocortin. The beta isoform of CRHR2 is expressed in the brain, while the alpha isoform is found in peripheral tissues. CRHR2 is thought to be involved in regulating changes to motivational states and craving in individuals undergoing drug withdrawal. CRHR2 participates in regulation of the stress response, and is involved in anxiety and mood-based disorders as well as post-traumatic stress disorder. In immunohistochemistry, CRHR2 has membranous and cytoplasmic positivity in the brain, thyroid, testes, and fallopian tube, with limited positivity in a few other tissues. References: Neuropsychopharmacology. 2015 Jul;40(8):1990-2000, PMID: 25672976; Depress Anxiety. 2013 Dec;30(12):1161-9, PMID: 24123648; Endocrinology. 1995 Sep; 136(9):4139-42, PMID: 7544278;
Target
Human CRHR2 / CRF2 Receptor
Synonyms
CRHR2 | CRF-R-2 | CRF-R2 | CRF2R | Crh2 receptor | CRF2 receptor, beta isoform | CRFR2 | CRFR-2 | CRH-R-2 | CRH2R | CRF-RB | CRF2 | CRH-R2 | HM-CRF
Host
Rabbit
Reactivity
Human, Monkey, Bovine, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Dog, Horse, Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 19 amino acid peptide from N-Terminus extracellular domain of human CRHR2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Bovine, Rabbit (100%); Mouse, Rat, Dog, Horse, Pig (95%); Opossum, Turkey, Lizard, Stickleback, Zebrafish (89%); Chicken (84%).
Epitope
N-Terminus
Specificity
Human CRHR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (8 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CRHR2 / CRF2 Receptor
Q13324 NM_001883 NP_001874.2

Validation

CRHR2 / CRF2 Receptor Antibody

CRHR2 / CRF2 Receptor Antibody - Anti-CRHR2 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CRHR2 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CRHR2 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ CRHR2 / CRF2 Receptor Antibody (N-Terminus) for IHC LS-A3570 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

Chronic stimulation of corticotropin-releasing factor receptor 1 enhances the anxiogenic response of the cholecystokinin system. Sherrin T, Todorovic C, Zeyda T, Tan CH, Wong PT, Zhu YZ, Spiess J. Molecular psychiatry. 2009 March;14:291-307.

Customer Reviews (0)


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Requested From: United States
Date Requested: 6/18/2024