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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16268-100 | 100 µg (0.2 mg/ml) | $525 |
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PathPlus™ Recombinant Monoclonal Rabbit anti‑Human CD68 Antibody (clone C68/2908R, IHC, WB) LS‑B16268
PathPlus™ Recombinant Monoclonal Rabbit anti‑Human CD68 Antibody (clone C68/2908R, IHC, WB) LS‑B16268
Note: This antibody replaces LS-C751482
Antibody:
CD68 Rabbit anti-Human Recombinant Monoclonal (C68/2908R) Antibody
Application:
IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
CD68 Rabbit anti-Human Recombinant Monoclonal (C68/2908R) Antibody
Application:
IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
CD68 (macrosialin) is a transmembrane glycoprotein of the LAMP family found in monocytes and macrophages. CD68 functions in antigen processing and in protecting the cell surface from hydrolytic enzymes. In immunohistochemistry, CD68 shows membranous expression in macrophages, monocytes, mast cells, plasmacytoid T cells within reactive lymph nodes, mononuclear phagocytes, and myeloid cells such as granulocytes. As a marker in cancer and disease, CD68 is positive in AML, CML, histiocytic neoplasms, melanomas, and some B-cell small lymphocytic lymphomas. Hairy-cell leukemias can also be weakly positive for CD68.
References: Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25): 14833–14838, PMID: 8962141; Lab Invest. 2017 Jan;97(1):4-13. doi: 10.1038/labinvest.2016.116. Epub 2016 Nov 21, PMID: 27869795
Target
Human CD68
Synonyms
CD68 | CD68 antigen | gp110 | SCARD1 | CD68 molecule | LAMP4 | Macrophage antigen CD68 | Macrosialin
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Recombinant Monoclonal
Clone
C68/2908R
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified.
Also available Azide-free, Carrier-free.
Immunogen
Recombinant full-length human LAMP4 protein. Antigen Molecular Weight: 110 kDa
Specificity
This antibody recognizes a glycoprotein of 110 kDa , which is identified as CD68. It is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells and macrophages in the red pulp of the spleen, in lamina propria of the gut, in lung alveoli, and in bone marrow. It reacts with myeloid precursors and peripheral blood granulocytes. It also reacts with plasmacytoid T cells, which are supposed to be of monocyte/macrophage origin. It shows strong granular cytoplasmic staining of chronic and acute myeloid leukemia and also reacts with rare cases of true histiocytic neoplasia. Lymphomas are negative or show few granules.
Applications
- IHC - Paraffin (1:100)
- Western blot (1 - 2 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistology (Formalin-fixed - 0.5-1 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CD68
Validation
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ CD68 Antibody (clone C68/2908R) for IHC, WB/Western LS-B16268 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Rat, Cat
Applications:
IHC, IHC - Paraffin
Species:
Rat
Applications:
IHC, IHC - Paraffin, IHC - Frozen
Species:
Mouse, Rat
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/28/2024
Date Requested: 4/28/2024
