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| Catalog Number | Size | Price |
|---|---|---|
| LS-B12522-100 | 100 µl (1 mg/ml) | $515 |
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PathPlus™ Polyclonal Rabbit anti‑Human BCL10 / BCL‑10 Antibody (aa111‑160, IHC, WB) LS‑B12522
PathPlus™ Polyclonal Rabbit anti‑Human BCL10 / BCL‑10 Antibody (aa111‑160, IHC, WB) LS‑B12522
Note: This antibody replaces LS-C198674
Antibody:
BCL10 / BCL-10 Rabbit anti-Human Polyclonal (aa111-160) Antibody
Application:
IHC, IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
BCL10 / BCL-10 Rabbit anti-Human Polyclonal (aa111-160) Antibody
Application:
IHC, IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Specifications
Description
BCL10 (B-cell lymphoma/leukemia 10) is a cellular homolog of the equine herpesvirus-2 E-10 gene that functions to induce apoptosis by activating CASP9. When overexpressed, BCL10 induces JNK, p38, and NF-kB activation. BCL10 plays an important role in both activating and suppressing adaptive and innate immune signaling by connecting to various CARD scaffold proteins. BCL10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas and participates in the pathogenesis of various malignancies. In immunohistochemistry of normal tissue, BLC10 has cytoplasmic positivity in most tissues throughout the body.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Front Immunol. 2018; 9: 1539, PMID: 30022982
Target
Human BCL10 / BCL-10
Synonyms
BCL10 | Bcl-10 | B-cell CLL/lymphoma 10 | B-cell lymphoma/leukemia 10 | CARMEN | CARD-like apoptotic protein | CCARMEN | C-E10 | CIPER | Cellular-E10 | HCLAP | Cellular homolog of vCARMEN | CLAP | ME10
Host
Rabbit
Reactivity
Human, Mouse, Rat
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic peptide from human BCL10. (AA Range: 111-160)
Epitope
aa111-160
Specificity
BCL10 Antibody detects endogenous levels of total BCL10 protein.
Applications
- IHC
- IHC - Paraffin (20 µg/ml)
- Western blot (1:500 - 1:1000)
- Peptide Enzyme-Linked Immunosorbent Assay (1:40000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Western Blot: Predicted MW 26 kDa
Presentation
PBS, pH 7.4, 150 mM NaCl, 0.02% Sodium Azide, 50% Glycerol
Storage
Store at -20°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
About BCL10 / BCL-10
Validation
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ BCL10 / BCL-10 Antibody (aa111-160) for IHC, WB/Western LS-B12522 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry, ELISA
Species:
Human, Dog
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Mouse
Applications:
IHC, ICC, Immunofluorescence, Western blot, Flow Cytometry, ELISA
Species:
Human, Mouse
Applications:
IHC, Immunofluorescence, Western blot, Flow Cytometry, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/28/2024
Date Requested: 4/28/2024
