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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-A266-50 50 µg (1 mg/ml) $425 
AVPR1B Antibody - Anti-AVPR1B antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
AVPR1B Antibody - Brain, Pituitary, pars anterior
AVPR1B Antibody - Anti-AVPR1B antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
AVPR1B Antibody - Anti-AVPR1B antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
AVPR1B Antibody - Anti-AVPR1B antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
AVPR1B Antibody - Anti-AVPR1B antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
AVPR1B Antibody - Brain, Pituitary, pars anterior
AVPR1B Antibody - Anti-AVPR1B antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
AVPR1B Antibody - Anti-AVPR1B antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
AVPR1B Antibody - Anti-AVPR1B antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human AVPR1B Antibody (N‑Terminus, IHC) LS‑A266

PathPlus™ Polyclonal Rabbit anti‑Human AVPR1B Antibody (N‑Terminus, IHC) LS‑A266

Antibody:
Rabbit Polyclonal to Human AVPR1B
Application:
IHC, IHC-P
Reactivity:
Human, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A266-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human AVPR1B
Application:
IHC, IHC-P
Reactivity:
Human, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
AVPR1B (vasopressin V1b receptor, V1BR) is a receptor for arginine vasopressin. It belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. AVPR1B has important functions in behavioral modulation, social recognition memory, social aggression, and regulation of hormonal stress. It is relevant to neuropsychiatric disorders including major depression, and specific haplotypes of AVPR1B seem to have protective effects against depressive disorders. In cancer, AVPR1B is expressed at high levels in ACTH-secreting pituitary adenomas, and it also has positivity in bronchial carcinoids (responsible for ectopic ACTH syndrome). In immunohistochemistry, AVPR1B has membranous positivity. The receptor is primarily located in anterior pituitary corticotrophs, where it stimulates ACTH release. However, it is also found in other regions in the brain, such as in hippocampal CA2 pyramidal cells, and may show limited extrapituitary positivity in the breast, lung, heart, kidney, thymus, spleen and uterus. References: Crit Care. 7 (6): 427–34, PMID: 14624682; Neuroscience. 143 (4): 1031–9, PMID: 17027167; Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6783-7, PMID: 7624319; Mol. Psychiatry. 9 (3): 287–92,. PMID: 15094789; J. Clin. Invest. 97 (5): 1311–8, PMID: 8636444; Front Neurosci. 2017 Oct 16;11:567
Target
Human AVPR1B
Synonyms
AVPR1B | AVPR3 | V1bR | AVPR V1b | AVPR V3 | V1b receptor | V1b vasopressin receptor | Vasopressin V1b receptor | Vasopressin V3 receptor | VPR3
Host
Rabbit
Reactivity
Human, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Monkey, Mouse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (4 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Failed Applications
  • ICC
  • Western blot
Immunogen
Synthetic 17 amino acid peptide from N-Terminus extracellular domain of human AVPR1B. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rat, Bovine, Dog, Bat, Elephant, Panda, Horse, Rabbit, Pig, Opossum (100%); Marmoset, Mouse (94%).
Blocking Peptide
LS-E28588 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A266. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
N-Terminus
Specificity
Human AVPR1B. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About AVPR1B
P47901 AF030512 BAA06621.1

Validation

AVPR1B Antibody - Anti-AVPR1B antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR1B antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR1B antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

AVPR1B Antibody - Brain, Pituitary, pars anterior
Brain, Pituitary, pars anterior
Brain, Pituitary, pars anterior

AVPR1B Antibody - Anti-AVPR1B antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR1B antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR1B antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

AVPR1B Antibody - Anti-AVPR1B antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR1B antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR1B antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

AVPR1B Antibody - Anti-AVPR1B antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR1B antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR1B antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ AVPR1B Antibody (N-Terminus) for IHC LS-A266 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

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Requested From: United States
Date Requested: 7/5/2020