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Catalog Number Size Price
LS-A1237-50 50 µg (1 mg/ml) $440 
ADORA2A/Adenosine A2A Receptor Antibody - Anti-ADORA2A antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ADORA2A/Adenosine A2A Receptor Antibody - Anti-ADORA2A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ADORA2A/Adenosine A2A Receptor Antibody - Anti-ADORA2A antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ADORA2A/Adenosine A2A Receptor Antibody - Anti-ADORA2A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human ADORA2A/Adenosine A2A Receptor Antibody (C‑Terminus, IHC) LS‑A1237

PathPlus™ Polyclonal Rabbit anti‑Human ADORA2A/Adenosine A2A Receptor Antibody (C‑Terminus, IHC) LS‑A1237

Antibody:
ADORA2A/Adenosine A2A Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$440
LS-A1237-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
ADORA2A/Adenosine A2A Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
ADORA2A (Adenosine A2A Receptor) is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. It is a receptor for adenosine and is also targeted by caffeine. ADORA2A amplifies intracellular cAMP levels after binding adenosine, and it is important for cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. Furthermore, natural increases in ADORA2A over time may be relevant to age-related decline in memory, and abrogation of the protein results in memory enhancements in mice. Along these lines, it is relevant to long-term memory storage and loss, and is thought to play a role in memory loss and the pathogenesis of related neurodegenerative disorders and inflammatory diseases. Levels of expression of this receptor have been found to be upregulated in astrocytes in Alzheimer’s disease patients and also in the early stages of Parkinson’s disease. In immunohistochemistry of normal tissue, ADORA2A has selective membranous positivity in the caudate nucleus in the brain and on populations of cells in the thymus, and is also expressed in vasculature and on platelets. References: Neurobiol Dis. 2014 Sep;69:206-14, PMID: 24892887; Nat Neurosci. 2015 Mar;18(3):423-34, PMID: 25622143; Nat Neurosci. 2015 Mar;18(3):423-34, PMID: 25622143; Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: 102776. https://omim.org;
Target
Human ADORA2A/Adenosine A2A Receptor
Synonyms
ADORA2A | Adenosine receptor A2a | ADORA2 | A2a receptor | Adenosine A2a receptor | Adenosine A2 receptor | Adenosine receptor subtype A2a | HA2aR | RDC8 | AA2AR | A2AR
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from C-Terminus cytoplasmic domain of human ADORA2A. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey, Marmoset (95%); Dog (80%).
Epitope
C-Terminus
Specificity
Human ADORA2A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Antigen retrieval requires Proteinase K treatment.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ADORA2A/Adenosine A2A Receptor
P29274 NM_000675 NP_000666.2

Validation

ADORA2A/Adenosine A2A Receptor Antibody - Anti-ADORA2A antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADORA2A antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADORA2A antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

ADORA2A/Adenosine A2A Receptor Antibody - Anti-ADORA2A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADORA2A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ADORA2A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ ADORA2A/Adenosine A2A Receptor Antibody (C-Terminus) for IHC LS-A1237 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/24/2021