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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A3434-50 50 µg (1 mg/ml) $425 
SLC7A11 / XCT Antibody - Anti-SLC7A11 antibody IHC of human chief cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PathPlus™ SLC7A11 / XCT Antibody N‑Terminus Polyclonal IHC LS‑A3434

PathPlus™ SLC7A11 / XCT Antibody N‑Terminus Polyclonal IHC LS‑A3434

Note: This antibody replaces LS-C89190, LS-C89189, LS-C42543
Antibody:
Rabbit Polyclonal to Human SLC7A11 / XCT
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A3434-50
50 µg
1 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human SLC7A11 / XCT
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
SLC7A11 (cystine/glutamate transporter, Xc-, xCT) is a chloride-dependent cystine-glutamate antiporter involved in excitatory signaling, glutamate release and modulation of synaptic activity. In addition to glutamatergic neurotransmission, it is thought to support neuroprotective processes related to oxidative stress. Dysfunctional glutamate signaling in neurological disorders such as schizophrenia may involve impairment of SLC7A11. In immunohistochemistry, SLC7A11 has high expression in astrocytes of the basolateral amygdala and prefrontal cortex in the brain, and it is also found in the eye, with low levels of additional expression in immune, reproductive and gastrointestinal tissues. Pharmacological Reviews. 64 (3): 780–802, PMID: 22759795; Journal of Psychiatric Research. 72: 58–63, PMID: 26540405; Glia. 2018 May;66(5):951-970, PMID: 29350434; NPJ Schizophr. 2017 Sep 18;3(1):31, PMID: 28924227; Antioxid Redox Signal. 2013 Feb 10; 18(5): 522–555, PMID: 22667998
Target
Human SLC7A11 / XCT
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 - 20 µg/ml)
  • Applications tested for the base form of this product only
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 19 amino acid peptide from N-terminus of human SLC7A11. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Monkey, Marmoset (95%); Horse (89%); Rat, Dog, Hamster (84%).
Blocking Peptide
LS-E28749 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A3434. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
N-Terminus
Specificity
Human SLC7A11. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Usage
Immunohistochemistry: The unconjugated form was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for the unconjugated form was determined to be 14-28 ug/ml.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About SLC7A11 / XCT
Q9UPY5 NM_014331 NP_055146.1

Validation

SLC7A11 / XCT Antibody - Anti-SLC7A11 antibody IHC of human chief cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SLC7A11 antibody IHC of human chief cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SLC7A11 antibody IHC of human chief cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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Requested From: United States
Date Requested: 11/12/2019