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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-A2447-50 50 µg (1 mg/ml) $425 
NR5A2 / LRH-1 Antibody - Breast, Carcinoma
NR5A2 / LRH-1 Antibody - Colon, Carcinoma
NR5A2 / LRH-1 Antibody - Lung, Non Small-Cell Carcinoma
NR5A2 / LRH-1 Antibody - Anti-LRH-1 / NR5A2 antibody IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml.
NR5A2 / LRH-1 Antibody - Anti-LRH-1 / NR5A2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml.
NR5A2 / LRH-1 Antibody - Non-Hodgkin's Lymphoma
NR5A2 / LRH-1 Antibody - Breast, Carcinoma
NR5A2 / LRH-1 Antibody - Colon, Carcinoma
NR5A2 / LRH-1 Antibody - Lung, Non Small-Cell Carcinoma
NR5A2 / LRH-1 Antibody - Anti-LRH-1 / NR5A2 antibody IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml.
NR5A2 / LRH-1 Antibody - Anti-LRH-1 / NR5A2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml.
NR5A2 / LRH-1 Antibody - Non-Hodgkin's Lymphoma
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PathPlus™ Polyclonal Rabbit anti‑Human NR5A2 / LRH‑1 Antibody (C‑Terminus, IHC) LS‑A2447

PathPlus™ Polyclonal Rabbit anti‑Human NR5A2 / LRH‑1 Antibody (C‑Terminus, IHC) LS‑A2447

Antibody:
Rabbit Polyclonal to Human NR5A2 / LRH-1
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bovine, Dog, Horse, Pig, Sheep
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A2447-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human NR5A2 / LRH-1
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bovine, Dog, Horse, Pig, Sheep
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Alpha1-fetoprotein transcription factor (Ftf), a NR5 fushi tarazu-like receptor, also is known as 'human B1-binding factor' (HB1F), 'CYP7A promoter-binding factor' (CPF), and 'liver receptor homolog 1' (LRH1). Ftf has been shown to affect the transcription of hepatic genes including alpha fetoprotein encoding gene (AFP), viral hepatitis B enhancer II, and 7-alpha-hydroxylase encoding gene (CYP7A1). Ftf has also been shown to affect hepatic cholesterol metabolism and bile acid synthesis. Ftf has been shown to regulate aromatase activities in adipose tissue, and alterations in Ftf expression and/or activity in adipose tissue could have considerable effects on local estrogen production and breast cancer development. LRH has been shown to expressly strongly in gonadal tissues, and may play an important role in the regulation of gonadal function. Three isoforms of Ftf have been identified: wild type (495 aa), CPF variant 1 (contains a 46-aa insertion in the A/B domain), and CPF variant 2 (contains a 172-aa deletion within the D/E domain). References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human NR5A2 / LRH-1
Synonyms
NR5A2 | B1F | B1F2 | B1-binding factor | CPF | CYP7A promoter-binding factor | FTZ-F1beta | FTF | Liver receptor homolog 1 | LRH1 | LRH-1 | HB1F | HB1F-2 | Nuclear receptor phr-1 | FTZ-F1 | Liver receptor homolog-1 | Nuclear receptor NR5A2 | Receptor phr
Host
Rabbit
Reactivity
Human, Monkey, Bovine, Dog, Horse, Pig, Sheep (tested or 100% immunogen sequence identity)
Predicted
Chicken, Xenopus (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (7 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 17 amino acid peptide from C-Terminus to ligand-binding domain of human NR5A2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Sheep, Bovine, Dog, Elephant, Panda, Horse, Pig (100%); Opossum, Turkey, Chicken, Platypus, Xenopus, Stickleback (94%); Mouse, Rat, Trout, Pufferfish, Zebrafish (88%).
Blocking Peptide
LS-E28556 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A2447. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
C-Terminus
Specificity
Human NR5A2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About NR5A2 / LRH-1
O00482 NM_003822 NP_003813.1

Validation

NR5A2 / LRH-1 Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

NR5A2 / LRH-1 Antibody - Colon, Carcinoma
Colon, Carcinoma
Colon, Carcinoma

NR5A2 / LRH-1 Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

NR5A2 / LRH-1 Antibody - Anti-LRH-1 / NR5A2 antibody IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml.
Anti-LRH-1 / NR5A2 antibody IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml.
Anti-LRH-1 / NR5A2 antibody IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml.

NR5A2 / LRH-1 Antibody - Anti-LRH-1 / NR5A2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml.
Anti-LRH-1 / NR5A2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml.
Anti-LRH-1 / NR5A2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml.

NR5A2 / LRH-1 Antibody - Non-Hodgkin's Lymphoma
Non-Hodgkin's Lymphoma
Non-Hodgkin's Lymphoma

LSBio Ratings

PathPlus™ NR5A2 / LRH-1 Antibody (C-Terminus) for IHC LS-A2447 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:16927-31. (IHC-P; Human)

Customer Reviews (0)


Requested From: United States
Date Requested: 5/24/2020