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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-A2099-50 50 µg (1 mg/ml) $425 
LTB4R2 / BLT2 Antibody - Breast, carcinoma
LTB4R2 / BLT2 Antibody - Colon, carcinoma
LTB4R2 / BLT2 Antibody - Lung, Adenocarcinoma
LTB4R2 / BLT2 Antibody - Anti-LTB4R2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LTB4R2 / BLT2 Antibody - Anti-LTB4R2 / BLT2 antibody IHC of human Colon, Carcinoma and Leukocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LTB4R2 / BLT2 Antibody - Anti-LTB4R2 / BLT2 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LTB4R2 / BLT2 Antibody - Breast, carcinoma
LTB4R2 / BLT2 Antibody - Colon, carcinoma
LTB4R2 / BLT2 Antibody - Lung, Adenocarcinoma
LTB4R2 / BLT2 Antibody - Anti-LTB4R2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LTB4R2 / BLT2 Antibody - Anti-LTB4R2 / BLT2 antibody IHC of human Colon, Carcinoma and Leukocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LTB4R2 / BLT2 Antibody - Anti-LTB4R2 / BLT2 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human LTB4R2 / BLT2 Antibody (Cytoplasmic Domain, IHC) LS‑A2099

PathPlus™ Polyclonal Rabbit anti‑Human LTB4R2 / BLT2 Antibody (Cytoplasmic Domain, IHC) LS‑A2099

Antibody:
Rabbit Polyclonal to Human LTB4R2 / BLT2
Application:
IHC, IHC-P, IHC-Fr, Flo
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A2099-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human LTB4R2 / BLT2
Application:
IHC, IHC-P, IHC-Fr, Flo
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
LTB4R2 is a low-affinity receptor for leukotrienes including leukotriene B4. It mediates the chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3. LTB4R2 has been found to be overexpressed in esophageal squamous cell cancer and may be involved in the early stages of carcinogenesis. In immunohistochemistry, LTB4R2 has membranous positivity in the spleen, thymus, tonsil, and lymph nodes, and is found on lymphocytes, macrophages, and potentially neutrophils. It is also present on neuronal subsets in the caudate nucleus, globus pallidus, subiculum, hippocampus, amygdala and tuberal nucleus within the central nervous system. It is positive in a wide range of cancers, including glioblastoma, breast cancer, colorectal adenocarcinoma, pulmonary adenocarcinoma, Hodgkin's disease, ovarian cancer, pancreatic cancer and lamignant melanoma. References: BMC Gastroenterol 16, 85 (2016), doi:10.1186/s12876-016-0499-z
Target
Human LTB4R2 / BLT2
Synonyms
LTB4R2 | BLT2 | BLTR2 | Blt-2 | BLT2R | JULF2 | LTB4-R2 | Hblt2 | KPG_004 | Leukotriene B4 receptor 2 | Leukotriene B4 receptor BLT2 | LTB4 receptor JULF2 | LTB4-R 2
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (26 µg/ml)
  • IHC - Frozen
  • Flow Cytometry
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human LTB4R2. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Mouse, Rat, Bat (88%); Elephant (81%).
Blocking Peptide
LS-E28494 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A2099. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Cytoplasmic Domain
Specificity
Human LTB4R2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About LTB4R2 / BLT2
Q9NPC1 NM_019839 NP_062813.2

Validation

LTB4R2 / BLT2 Antibody - Breast, carcinoma
Breast, carcinoma
Breast, carcinoma

LTB4R2 / BLT2 Antibody - Colon, carcinoma
Colon, carcinoma
Colon, carcinoma

LTB4R2 / BLT2 Antibody - Lung, Adenocarcinoma
Lung, Adenocarcinoma
Lung, Adenocarcinoma

LTB4R2 / BLT2 Antibody - Anti-LTB4R2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LTB4R2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LTB4R2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LTB4R2 / BLT2 Antibody - Anti-LTB4R2 / BLT2 antibody IHC of human Colon, Carcinoma and Leukocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LTB4R2 / BLT2 antibody IHC of human Colon, Carcinoma and Leukocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LTB4R2 / BLT2 antibody IHC of human Colon, Carcinoma and Leukocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LTB4R2 / BLT2 Antibody - Anti-LTB4R2 / BLT2 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LTB4R2 / BLT2 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LTB4R2 / BLT2 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ LTB4R2 / BLT2 Antibody (Cytoplasmic Domain) for IHC, Flow LS-A2099 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (5)

Publications (2)

Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. Bck M, Bu DX, Brnstrm R, Sheikine Y, Yan ZQ, Hansson GK. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:17501-6. (IHC-Fr; Human)

Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2. Seo JM, Park S, Kim JH. The Journal of biological chemistry. 2012 Apr;287:13840-9.

Customer Reviews (0)


Requested From: United States
Date Requested: 7/11/2020