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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A6816-50 50 µg (0.7 mg/ml) $425 
HRH4 / Histamine H4 Receptor Antibody - Lung, Non Small-Cell Carcinoma
HRH4 / Histamine H4 Receptor Antibody - Pancreas, carcinoma
HRH4 / Histamine H4 Receptor Antibody - Ovary, carcinoma
HRH4 / Histamine H4 Receptor Antibody - Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Colon, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
HRH4 / Histamine H4 Receptor Antibody - Anti-HRH4 / Histamine H4 Receptor antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
HRH4 / Histamine H4 Receptor Antibody - Colon, Carcinoma
HRH4 / Histamine H4 Receptor Antibody - Lung, Non Small-Cell Carcinoma
HRH4 / Histamine H4 Receptor Antibody - Pancreas, carcinoma
HRH4 / Histamine H4 Receptor Antibody - Ovary, carcinoma
HRH4 / Histamine H4 Receptor Antibody - Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Colon, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
HRH4 / Histamine H4 Receptor Antibody - Anti-HRH4 / Histamine H4 Receptor antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
HRH4 / Histamine H4 Receptor Antibody - Colon, Carcinoma
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PathPlus™ Polyclonal HRH4 / Histamine H4 Receptor Antibody (Cytoplasmic Domain, IHC) LS‑A6816

PathPlus™ Polyclonal HRH4 / Histamine H4 Receptor Antibody (Cytoplasmic Domain, IHC) LS‑A6816

Note: This antibody replaces LS-C67893
Antibody:
Rabbit Polyclonal to Human HRH4 / Histamine H4 Receptor
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A6816-50
50 µg
0.7 mg/ml

Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human HRH4 / Histamine H4 Receptor
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
HRH4 (Histamine receptor H4) is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. HRH4 is thought to play a role in inflammation and allergy reponses, and controls neutrophil release from bone marrow. It also plays a role in determining eosinophil shape change as well as mast cell chemotaxis and calcium mobilization. Loss of HRH4 in gastric carcinomas through deletion is also thought to play a role in cancer growth. References: J. Pharmacol. Exp. Ther. 2003. 305 (3): 1212–21. doi:10.1124/jpet.102.046581. PMID 12626656; PLoS One. 2012;7(2):e31207, PMID: 22363581
Target
Human HRH4 / Histamine H4 Receptor
Synonyms
HRH4 | BG26 | G-protein coupled receptor 105 | GPRv53 | H4 | HH4R | Histamine H4 receptor | GPCR105 | H4R | Pfi-013 | SP9144 | AXOR35 | Gprc105 | H4 histamine receptor | Histamine receptor H4
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (14 µg/ml)
  • Applications tested for the base form of this product only
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 21 amino acid peptide from 3rd cytoplasmic domain of human HRH4 / Histamine H4 Receptor. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Marmoset (90%); Monkey (81%).
Blocking Peptide
LS-E29195 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A6816. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Cytoplasmic Domain
Specificity
Human HRH4 / Histamine H4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About HRH4 / Histamine H4 Receptor
Q9H3N8 AY136745 NP_067637.2

Validation

HRH4 / Histamine H4 Receptor Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

HRH4 / Histamine H4 Receptor Antibody - Pancreas, carcinoma
Pancreas, carcinoma
Pancreas, carcinoma

HRH4 / Histamine H4 Receptor Antibody - Ovary, carcinoma
Ovary, carcinoma
Ovary, carcinoma

HRH4 / Histamine H4 Receptor Antibody - Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Colon, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Colon, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human Colon, Carcinoma and Inflammatory Cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

HRH4 / Histamine H4 Receptor Antibody - Anti-HRH4 / Histamine H4 Receptor antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HRH4 / Histamine H4 Receptor antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

HRH4 / Histamine H4 Receptor Antibody - Colon, Carcinoma
Colon, Carcinoma
Colon, Carcinoma

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Requested From: United States
Date Requested: 2/18/2020