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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-A78-50 50 µg (1 mg/ml) $425 
GPR12 Antibody - Anti-GPR12 / GPCR12 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR12 Antibody - Ovary, Carcinoma
GPR12 Antibody - Anti-GPR12 / GPCR12 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR12 Antibody - Ovary, Carcinoma
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PathPlus™ Polyclonal GPR12 Antibody (C‑Terminus, IHC, WB) LS‑A78

PathPlus™ Polyclonal GPR12 Antibody (C‑Terminus, IHC, WB) LS‑A78

Antibody:
Rabbit Polyclonal to Human GPR12
Application:
IHC, IHC-P, WB
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A78-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human GPR12
Application:
IHC, IHC-P, WB
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
G protein-coupled receptor 12 (GPR12) is a constitutively active Lysophospholipid/Lysosphingolipid receptor. It promotes neurite outgrowth and blocks myelin inhibition in neurons, and it also stimulates cyclic AMP production. In immunohistochemistry, GPR12 has highest membranous positivity in the basal ganglia, cerebellum and cerebral cortex in the brain, and it is found at moderate to low levels throughout the nervous system. It has additional positivity in the salivary gland, skin, and breast, and potentially at low levels in other tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GPR12
Synonyms
GPR12 | G protein-coupled receptor 12 | G-protein coupled receptor 12 | GPCR12 | GPCR21
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Predicted
Mouse, Dog, Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (2 - 4 µg/ml)
  • Western blot (1:1000 - 1:2000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 16 amino acid peptide from C-Terminus of human GPR12 / GPCR12. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Mouse, Panda, Dog, Pig (94%); Hamster, Elephant, Bat, Horse, Rabbit, Opossum, Turkey (88%); Rat, Bovine, Chicken, Platypus, Xenopus, Stickleback (81%).
Epitope
C-Terminus
Specificity
Human GPR12 / GPCR12. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except REM1 (50%).
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GPR12
P47775 NM_005288 NP_005279.1

Validation

GPR12 Antibody - Anti-GPR12 / GPCR12 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR12 / GPCR12 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR12 / GPCR12 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR12 Antibody - Ovary, Carcinoma
Ovary, Carcinoma
Ovary, Carcinoma

LSBio Ratings

PathPlus™ GPR12 Antibody (C-Terminus) for IHC, WB/Western LS-A78 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 4/9/2020