Products
Services
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Catalog Number Size Price
LS-A3484-50 50 µg (0.7 mg/ml) $425 
FZD1 / Frizzled 1 Antibody - Breast, Carcinoma
FZD1 / Frizzled 1 Antibody - Brain, Glioblastoma
FZD1 / Frizzled 1 Antibody
FZD1 / Frizzled 1 Antibody - Lung, non small-cell carcinoma
FZD1 / Frizzled 1 Antibody - Lung, Non Small-Cell Carcinoma
FZD1 / Frizzled 1 Antibody - Anti-FZD1 / Frizzled 1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD1 / Frizzled 1 Antibody - Anti-FZD1 / Frizzled 1 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD1 / Frizzled 1 Antibody - Ovary, Carcinoma
FZD1 / Frizzled 1 Antibody - Breast, Carcinoma
FZD1 / Frizzled 1 Antibody - Brain, Glioblastoma
FZD1 / Frizzled 1 Antibody
FZD1 / Frizzled 1 Antibody - Lung, non small-cell carcinoma
FZD1 / Frizzled 1 Antibody - Lung, Non Small-Cell Carcinoma
FZD1 / Frizzled 1 Antibody - Anti-FZD1 / Frizzled 1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD1 / Frizzled 1 Antibody - Anti-FZD1 / Frizzled 1 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD1 / Frizzled 1 Antibody - Ovary, Carcinoma
1 of 8
2 of 8
3 of 8
4 of 8
5 of 8
6 of 8
7 of 8
8 of 8

PathPlus™ Polyclonal Rabbit anti‑Human FZD1 / Frizzled 1 Antibody (N‑Terminus, IHC) LS‑A3484

PathPlus™ Polyclonal Rabbit anti‑Human FZD1 / Frizzled 1 Antibody (N‑Terminus, IHC) LS‑A3484

Antibody:
Rabbit Polyclonal to Human FZD1 / Frizzled 1
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A3484-50
50 µg
0.7 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human FZD1 / Frizzled 1
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human FZD1 / Frizzled 1
Synonyms
FZD1 | Chfz-1 | Fz1 | Frizzled 1 | Fz receptor 1 | HFz1 | Frizzled homolog 1 | Fz-1 | FzE1 | Rfz1 | Xfrizzled-1 | Wnt receptor | Dfrizzled-1 | Frizzled family receptor 1 | Frizzled-1
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (7 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 17 amino acid peptide from N-Terminus extracellular domain of human FZD1 / Frizzled 1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Baboon, Monkey, Marmoset, Mouse, Rat, Shrew, Hamster, Panda, Dog, Bat, Bovine, Horse, Rabbit, Opossum, Armadillo (100%); Elephant (94%).
Blocking Peptide
LS-E28763 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A3484. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
N-Terminus
Specificity
Human FZD1 / Frizzled 1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About FZD1 / Frizzled 1
Q9UP38 NM_003505 NP_003496.1

Validation

FZD1 / Frizzled 1 Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

FZD1 / Frizzled 1 Antibody - Brain, Glioblastoma
Brain, Glioblastoma
Brain, Glioblastoma

FZD1 / Frizzled 1 Antibody

FZD1 / Frizzled 1 Antibody - Lung, non small-cell carcinoma
Lung, non small-cell carcinoma
Lung, non small-cell carcinoma

FZD1 / Frizzled 1 Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

FZD1 / Frizzled 1 Antibody - Anti-FZD1 / Frizzled 1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD1 / Frizzled 1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD1 / Frizzled 1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FZD1 / Frizzled 1 Antibody - Anti-FZD1 / Frizzled 1 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD1 / Frizzled 1 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD1 / Frizzled 1 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FZD1 / Frizzled 1 Antibody - Ovary, Carcinoma
Ovary, Carcinoma
Ovary, Carcinoma

LSBio Ratings

PathPlus™ FZD1 / Frizzled 1 Antibody (N-Terminus) for IHC LS-A3484 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Requested From: United States
Date Requested: 6/7/2020