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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-B2842-50 50 µl (1 mg/ml) $425 
BMP4 Antibody - Anti-BMP4 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
BMP4 Antibody
BMP4 Antibody - Anti-BMP4 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
BMP4 Antibody
1 of 2
2 of 2

PathPlus™ Polyclonal Rabbit anti‑Human BMP4 Antibody (IHC, WB) LS‑B2842

PathPlus™ Polyclonal Rabbit anti‑Human BMP4 Antibody (IHC, WB) LS‑B2842

Note: This antibody replaces LS-C62252
Antibody:
Rabbit Polyclonal to Human BMP4
Application:
IHC, IHC-P, WB
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Goat, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B2842-50
50 µl
1 mg/ml
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human BMP4
Application:
IHC, IHC-P, WB
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Goat, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus
Format:
Unconjugated, Unmodified

Specifications

Description
BMP4 (BMP2B, ZYME) is a 116-residue, highly conserved bone morphogenic protein that plays an important role in neural stem cell signaling during embryonic development. It regulates the growth and differentiation of neural precursor cells into neuronal and glial cells during embryogenesis and also in the injured central nervous system (CNS). It promotes astrocyte differentiation and is necessary for suppressing the differentiation of oligodendrocyte progenitor cells into oligodendrocytes. It is upregulated in injured tissue in the CNS. It is also upregulated in demyelination diseases, and it is possible that suppressing or altering BMP4 expression may result in remyelination and potentially provide a means of restoring cognitive or motor function. In immunohistochemistry, BMP4 has extracellular and secretory positivity in smooth muscle, the lung, the kidney at low levels, the normal prostate, and also neoplastic and cancerous prostate tissue. References: Stem Cells Int. 2016; 2016: 9260592, PMID: 27293450; Vitam Horm. 2015;99:195-222, PMID: 26279377;
Target
Human BMP4
Synonyms
BMP4 | BMP-2B | BMP-4 | BMP2B | BMP2B1 | Bone morphogenetic protein 2B | Bone morphogenetic protein 4 | DVR4 | MCOPS6 | OFC11 | Zyme
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Goat, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:100)
  • Western blot (1:2000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide (DEYDKVVLKNYQEC). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Baboon, Monkey, Galago, Marmoset, Mouse, Rat, Shrew, Goat, Hamster, Elephant, Panda, Bat, Dog, Bovine, Horse, Rabbit, Pig, Opossum, Chicken, Xenopus, Medaka (100%); Salmon, Stickleback, Pufferfish (92%); Sheep, Water flea (85%).
Usage
Immunohistochemistry: LS-B2842 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2842 was determined to be 1:100.
Presentation
HEPES, 0.15 M NaCl, 0.03% Sodium Azide, 50% Glycerol, 0.01% BSA
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About BMP4
P12644 NM_001202 NP_001193.2

Validation

BMP4 Antibody - Anti-BMP4 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-BMP4 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-BMP4 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

LSBio Ratings

PathPlus™ BMP4 Antibody for IHC, WB/Western LS-B2842 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 7/10/2020