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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-B6259-50 50 µl $425 
APCS / Serum Amyloid P / SAP Antibody - Anti-Serum Amyloid P antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
APCS / Serum Amyloid P / SAP Antibody
APCS / Serum Amyloid P / SAP Antibody - Anti-Serum Amyloid P antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
APCS / Serum Amyloid P / SAP Antibody
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PathPlus™ Monoclonal Mouse anti‑Human APCS / Serum Amyloid P / SAP Antibody (clone 6E6, IHC, WB) LS‑B6259

PathPlus™ Monoclonal Mouse anti‑Human APCS / Serum Amyloid P / SAP Antibody (clone 6E6, IHC, WB) LS‑B6259

Note: This antibody replaces LS-C62014
Antibody:
Mouse Monoclonal to Human APCS / Serum Amyloid P / SAP
Application:
IHC, IHC-P, WB, IP, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B6259-50
50 µl
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Mouse Monoclonal to Human APCS / Serum Amyloid P / SAP
Application:
IHC, IHC-P, WB, IP, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
APCS (Serum Amyloid P Component / SAP) is a glycoprotein belonging to the pentraxin family of proteins. In the brain of patients with Alzheimer’s disease, APCS binds to amyloid fibrils and paired helical filaments and is present in cerebrospinal fluid, neurofibrillary tangles and amyloid plaques. It is used as a marker for amyloid deposits in immunohistochemistry. Roughly 14% of the dry mass of amyloid deposits is composed of APCS, and it is a likely contributor to the pathogenesis of amyloidosis. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin, and it has been demonstrated that APCS binds to apoptotic cells at an early stage. In immunohistochemistry of normal tissue, APCS is positive in plasma and in hepatocytes in the liver. References: Nature Medicine. 1997. 3 (8): 855–9, PMID: 9256275; PLoS One. 2016 Jul 18;11(7):e0159294, PMID: 27428539; Dementia. 1996 Sep-Oct;7(5):256-9, PMID: 8872416; PNAS May 5, 2009 106 (18) 7619-7623; PMID: 10.1073/pnas.0902640106; Cellular and Molecular Pathobiology of Cardiovascular Disease. Academic Press. 2014 Jan. 32. ISBN: 9780124052062;
Target
Human APCS / Serum Amyloid P / SAP
Synonyms
APCS | 9.5S alpha-1-glycoprotein | Amyloid P component, serum | Pentaxin-related | PTX2 | Serum Amyloid P | Serum amyloid P-component | SAP
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Clone
6E6
Conjugations
Unconjugated
Purification
Ammonium sulfate precipitation
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:200)
  • Western blot (1:1000)
  • Immunoprecipitation
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Protein purified from Human plasma
Presentation
HEPES, 0.15 M NaCl, 0.03% Sodium Azide, 50% Glycerol, 0.01% BSA
Storage
Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About APCS / Serum Amyloid P / SAP
P02743 NM_001639 NP_001630.1

Validation

APCS / Serum Amyloid P / SAP Antibody - Anti-Serum Amyloid P antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-Serum Amyloid P antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-Serum Amyloid P antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.

LSBio Ratings

PathPlus™ APCS / Serum Amyloid P / SAP Antibody (clone 6E6) for IHC, WB/Western, IP, ELISA LS-B6259 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 6/5/2020