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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-B4696-50 50 µg (1 mg/ml) $545 
TLR4 Antibody - Anti-TLR4 antibody IHC of human neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
TLR4 Antibody - Anti-TLR4 antibody IHC of human neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
TLR4 Antibody - Anti-TLR4 antibody IHC of human neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
TLR4 Antibody - Anti-TLR4 antibody IHC of human neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PathPlus™ TLR4 Antibody Polyclonal ELISA,IHC LS‑B4696

PathPlus™ TLR4 Antibody Polyclonal ELISA,IHC LS‑B4696

Note: This antibody replaces LS-C114217
Antibody:
Rabbit Polyclonal to Human TLR4
Application:
IHC, IHC-P, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$545 
LS-B4696-50
50 µg
1 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human TLR4
Application:
IHC, IHC-P, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
TLR4 (Toll-like receptor 4) is a transmembrane protein involved in the immune response, inflammation, and cytokine secretion. TLR4 activates the NF-kappa-B (NFKB) and po-Interleukin-1 beta (IL1B) pathways in the brain and is thus relevant to neuro-inflammation and pathological neurodegenerative conditions. It has been found to positively regulate the proliferation of Schwann cells in the peripheral nervous system, it is upregulated in injured nerves, and it is involved in inflammation in brain injury. TLR4 is also expressed in astrocytes and neurons as part of the immune response to bacterial lipopolysaccharide (LPS). Likewise, mutations in TLR4 lead to susceptibility to infections by gram-negative bacteria. Additionally, TLR4 is expressed on many cancer cells, where it may increase proliferative capacity and resistance to therapies. In immunohistochemistry of normal tissue, TLR4 has highest cytoplasmic positivity in immune cells, in the placenta, and in microglia and neurons in the brain. Archives of Internal Medicine. 162 (9): 1028–32,PMID: 11996613; Cytokine. 89: 127–135, PMID: 26854213; Sci Rep. 2018; 8: 11179, PMID: 30046125; Front Immunol. 2019 May 10;10:1000, PMID: 31134076; Front Immunol. 2019 May 10;10:1000, PMID: 31134076
Target
Human TLR4
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Peptide Column Affinity Chromatography
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
A 14 amino acid synthetic peptide near the C-Terminus of human TLR4. The immunogen is located within the last 50 amino acids of TLR4.
Blocking Peptide
LS-E30018 - Liquid - 0.05 mg - $145.00
Immunizing peptide used to generate LS-B4696. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Specificity
TLR4 antibody is predicted to not cross-react with other TLR protein family members.
Usage
TLR4 antibody can be used for detection of TLR4 by immunohistochemistry at 5 ug/mL. Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Western Blot:
Presentation
PBS containing 0.02% Sodium Azide
Storage
Store at 4°C for up 3 months. Store at -20°C for up to 1 year. Avoid freeze/thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About TLR4
O00206 NM_138554 O00206

Validation

TLR4 Antibody - Anti-TLR4 antibody IHC of human neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-TLR4 antibody IHC of human neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-TLR4 antibody IHC of human neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

TLR4 Antibody - Anti-TLR4 antibody IHC of human neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-TLR4 antibody IHC of human neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-TLR4 antibody IHC of human neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

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Requested From: United States
Date Requested: 12/5/2019