Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Recognizes mouse C3. Significant cross reaction is observed with pooled normal plasma from rat and rabbit. Pooled normal plasma from human, pig, rabbit, sheep, canine, and horse were assayed for cross-reactivity. No significant crossreactivity was observed.
LS-F10438 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Complement C3 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C3 as low as 0.0719 nanograms per millilter.
1:100,000-1:1,000,000 (Plasma, Serum)
96-Well Strip Plate
Colorimetric - 450nm (TMB)
0.1 - 100 ng/ml
Due to their limited shelf life, LSBio ELISA kits are not typically stocked as finished goods. Upon receipt of an order each kit is assembled and tested to ensure that it meets specifications before shipping. Minor changes may occur to the Range, Sensitivity, and Precision. In the event of a significant change the order would be confirmed with the customer before shipping ELISA kit lot numbers reflect the date of final assembly and testing for each specific kit rather than a bulk manufactured lot. All kits are tested to confirm that they fall within their defined Inter- and Intra- assay coefficient of variation.
Complement Component 3 (C3), the most abundant serum complement component, is a disulfide-linked 185kDa 1,637 amino acid glycoprotein which supports the classical, alternative, and lectin pathways of complement activation. C3 is proteolytically activated by C3-convertase to the anaphylatoxin C3a and the opsonizing agent C3b. Serum concentrations of C3 are increased during acute and chronic inflammation such as rheumatoid arthritis, and are decreased due to increased consumption or autoimmune disorders such as systemic lupus erythematosus.
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process.