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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cathepsin K Inhibitor Screening Kit (Fluorometric) - LS-K342

Available for shipment within the USA only
Assay Kit
Catalog
Size
Price
LS-K342-100
100 asy
$785

Available for shipment within the USA only

Product Description

Cathepsin K (CTSK, EC 3.4.22.38), a lysosomal cysteine protease, is involved in osteoclastic bone remodeling and resorption. In addition, it also degrades collagen, gelatin and elastin. The Cathepsin K Inhibitor Screening Kit utilizes the ability of active Cathepsin K to cleave the synthetic AFC based peptide substrate to release AFC, which can be easily quantified using a fluorometer or fluorescence microplate reader. In the presence of a Cathepsin K-specific inhibitor, the cleavage of this substrate is reduced/abolished resulting in decrease or total loss of the AFC fluorescence. This simple and high-throughput adaptable assay kit can be used to screen/study/characterize potential inhibitors of Cathepsin K.

Specifications

Name
Cathepsin K Inhibitor Screening Kit (Fluorometric)
Product Type
Inhibitor Screening
Usage Summary
Screen/study/characterize potential inhibitors of Cathepsin K.
Target
CTSK / Cathepsin K
Detection
Fluorometric (Ex/Em 400/505 nm)
Kit Components
  • CTSK Reaction Buffer
  • CTSK Reagent
  • Cathepsin K (Human)
  • CTSK Substrate
  • Ac-LR-AFC (10 mM)
  • CTSK Inhibitor (FF-FMK
  • 1 mM)
  • (See Datasheet for specific volumes supplied)
  • Applications
    Spectrophotometry (fluorometric)
    Equipment
    Microplate fluorometer
    Conditions
    Shipped -20°C Dry Ice, Store at Store at -80°C for up to 1 year., 12 months shelf life.
    Documents
    Data Sheet Data Sheet    SDS SDS
    Restrictions
    For research use only. Available for shipment within the USA only.
    About CTSK / Cathepsin K
    P43235 NM_000396 NP_000387.1

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    Requested From: United States
    Date Requested: 5/20/2019
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