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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cathepsin K Activity Kit (Fluorometric) - LS-K71

Available for shipment within the USA only
100 asy

Available for shipment within the USA only

Product Description

Apoptosis can be mediated by mechanisms other than the traditional caspase-mediated cleavage cascade. There is growing recognition that alternative proteolytic enzymes such as the lysosomal cathepsin proteases may initiate or propagate proapoptotic signals. Cathepsins are lysosomal enzymes that are also used as sensitive markers in various toxicological investigations. The Cathepsin-K Activity Assay kit is a fluorescence-based assay that utilizes the preferred cathepsin-K substrate sequence LR labeled with AFC (amino-4-trifluoromethyl coumarin). Cell lysates or other samples that contain cathepsin-K will cleave the synthetic substrate LR-AFC to release free AFC. The released AFC can easily be quantified using a fluorometer or fluorescence plate reader. The cathepsin-K assay is simple, straightforward, and can be adapted to 96-well plate assays. Assay conditions have been optimized to obtain the maximal activity.


Cathepsin K Activity Kit (Fluorometric)
Product Type
Enzymatic Activity Assay
Usage Summary
This assay provides for the detection of Cathepsin-K in various biological sample types. Detects alternative proteolytic enzymes such as the lysosomal cathepsin proteases that can initiate or propagate proapoptotic signals.
CTSK / Cathepsin K
Sample Type
Cell Lysates, Tissue Homogenates
Fluorometric (Ex/Em 400/505 nm)
Species Reactivity
Spectrophotometry (fluorometric)
Microplate fluorometer, Cuvette
Shipped -20°C Dry Ice, Store at Store at -20°C., 6-12 months shelf life.
Data Sheet Data Sheet    SDS SDS
For research use only. Available for shipment within the USA only.
About CTSK / Cathepsin K
P43235 NM_000396 NP_000387.1

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Requested From: United States
Date Requested: 5/20/2019
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