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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
Protein Family And Group
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LSBio
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Seattle WA 98121
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Caspase-1 Inhibitor Drug Screening Kit (Fluorometric) - LS-K344

Available for shipment within the USA only
Assay Kit
Catalog
Size
Price
LS-K344-100
100 asy
$680

Available for shipment within the USA only

Product Description

Caspases have been shown to play a crucial role in apoptosis induced by various deleterious and physiologic stimuli. Inhibition of caspases can delay apoptosis, implicating a potential role in drug screening efforts. The Caspase-1 Inhibitor Drug Screening Kit provides an effective means for screening caspase inhibitors using fluorometric methods. The assay utilizes synthetic peptide substrate YVAD-AFC (AFC, 7-amino-4-trifluoromethyl coumarin). Active caspase-1 cleaves the synthetic substrate to release free AFC which can then be quantified by fluorometry. Compounds to be screened can directly be added to the reaction and the level of inhibition of caspase-1 activity can be determined by comparison of the fluorescence intensity in samples with and without the testing inhibitors.

Specifications

Name
Caspase-1 Inhibitor Drug Screening Kit (Fluorometric)
Product Type
Inhibitor Screening
Usage Summary
Effective means for screening caspase inhibitors using fluorometric methods.
Target
CASP1 / Caspase 1
Detection
Fluorometric (Ex/Em 400/505 nm)
Species Reactivity
Mammal
Kit Components
  • 2X Reaction Buffer
  • Caspase Substrate YVAD-AFC (1 mM)
  • DTT (1 M)
  • Active Caspase-1 (Lyophilized)
  • Caspase Inhibitor
  • Z-VAD-FMK (2 mM)
  • (See Datasheet for specific volumes supplied)
  • Applications
    Spectrophotometry (fluorometric)
    Equipment
    Microplate fluorometer
    Conditions
    Shipped -20°C Dry Ice, Store at -20°C for 6-12 months, 6-12 months shelf life.
    Documents
    Data Sheet Data Sheet    SDS SDS
    Restrictions
    For research use only. Available for shipment within the USA only.
    About CASP1 / Caspase 1
    P29466 NM_001223 NP_001214.1

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    Requested From: United States
    Date Requested: 9/21/2019