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Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.
Gene Name: | zinc finger, MYND-type containing 11 |
Synonyms: | ZMYND11, Protein BS69, RP11-486H9.1, BRAM1, BS69 |
Target Sequences: | NM_006624 |
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