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UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
Gene Name: | UV radiation resistance associated |
Synonyms: | UVRAG, DHTX, Beclin 1 binding protein, VPS38, Disrupted in heterotaxy, p63 |
Target Sequences: | NM_003369 NP_003360.2 Q9P2Y5 |
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