Bovine Ubiquitin

Sheep

Bovine (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Protein G purified

Unmodified

Native ubiquitin from bovine erythrocytes.

Recognizes ubiquitin, a 8.6kD cytoplasmic and nuclear protein which is highly conserved across species. Ubiquitin functions as a protein modifier which covalently attaches to lysines as either a monomer or as a lysine-linked polymer. Attachment as a Lys-48 polymer usually leads to the target protein undergoing proteolytic degradation. Attachment as a monomer does not result in degradation and may be linked to functions including maintenance of chromatin structure, regulation of gene expression, stress response and DNA repair. Ubiquitin can be detected in both normal and diseased brain tissues including the neurofibrillary tangles of Alzheimer's disease, Lewy bodies in Parkinson's disease and Pick bodies in Picka€™s disease.

• ELISA (1:100 - 1:2000)

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

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