Target
Human TRIM33 / TIF1-Gamma
Synonyms
TRIM33 | Ectodermin homolog | ECTO | RET-FUSED GENE 7 | RFG7 | TF1G | TIF1GAMMA | TIFGAMMA | TIF1-gamma | PTC7 | RET-fused gene 7 protein | TIF1G | Tripartite motif-containing 33 | KIAA1113 | Protein Rfg7 | Tripartite motif containing 33
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant Human E3 ubiquitin-protein ligase TRIM33 protein (1-273AA)
Specificity
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).