Mouse TREM1

Rat

Mouse (tested or 100% immunogen sequence identity)

IgG2a Monoclonal

L5-B8.2A12.3A12

Unconjugated. Also available conjugated with RPE, FITC.

Protein G purified

Unmodified. Also available Low Endotoxin.

Mouse TREM-1 Fc fusion protein.

Recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes, which is reported to act as an inhibitor of TREM-1. TREM-1 mediates the septic shock pathway, and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection.

• IHC - Frozen
• Immunofluorescence
• Western blot
• Flow Cytometry (1:25 - 1:100)

• IHC - Paraffin

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9NP99 NCBI: NM_018643 NP_061113.1