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TPD52L1 encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.
Gene Name: | tumor protein D52-like 1 |
Synonyms: | TPD52L1, HD53, Tumor protein D53, D53, Tumor protein D52-like 1 |
Target Sequences: | NM_003287 NP_003278.1 Q16890 |
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