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TNC / Tenascin C
tenascin C
Tenascin C (TNC) is the founding member of the gene family. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and cartilage. The basic structure is 14 EGF-like repeats towards the N-terminal end, and 8 or more fibronectin-III domains which vary upon species and variant. TNC has anti-adhesive properties, causing cells in tissue culture to become rounded after it is added to the medium. One mechanism to explain this may come from its ability to bind to the extracellular matrix glycoprotein fibronectin and block fibronectin's interactions with specific syndecans. The expression of tenascin-C in the stroma of certain tumors is associated with a poor prognosis.
| Gene Name: | tenascin C |
| Family/Subfamily: | Fibronectin , not assigned-Fibronectin |
| Synonyms: | TNC, 150-225, Cytotactin, GP, Hexabrachion (tenascin), GMEM, GP 150-225, Miotendinous antigen, Myotendinous antigen, JI, Tenascin, Tenascin C, Neuronectin, Tenascin-C isoform 14/AD1/16, TN-C, Hexabrachion, HXB, Tenascin-C, TN |
| Target Sequences: | NM_002160 NP_002151.2 P24821 |
Publications (15)
1
Involvement of large tenascin-C splice variants in breast cancer progression. Tsunoda T, Inada H, Kalembeyi I, Imanaka-Yoshida K, Sakakibara M, Okada R, Katsuta K, Sakakura T, Majima Y, Yoshida T. The American journal of pathology. 2003 162:1857-67.
[PubMed:12759243]
[PMC:PMC1868127]
2
Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury. Tamaoki M, Imanaka-Yoshida K, Yokoyama K, Nishioka T, Inada H, Hiroe M, Sakakura T, Yoshida T. The American journal of pathology. 2005 167:71-80.
[PubMed:15972953]
[PMC:PMC1603439]
3
Switch to an invasive growth phase in melanoma is associated with tenascin-C, fibronectin, and procollagen-I forming specific channel structures for invasion. Kriinen E, Nummela P, Soikkeli J, Yin M, Lukk M, Jahkola T, Virolainen S, Ora A, Ukkonen E, Saksela O, Hltt E. The Journal of pathology. 2006 210:181-91.
[PubMed:16924594]
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Publications
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(151)
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(1)
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(3)
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(17)
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(17)
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(4)
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(3)
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(5)
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Neuroscience
TNC / Tenascin C Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µl/$440
TNC / Tenascin C Mouse anti-Human Monoclonal (SPM319) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
TNC / Tenascin C Mouse anti-Human Monoclonal (Concentrated) (DB7) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated, Concentrated
1 ml/$563
TNC / Tenascin C Mouse anti-Human Monoclonal (T2H5) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.2 mg/$471
TNC / Tenascin C Rabbit anti-Chicken Polyclonal Antibody
Chicken
IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$842
TNC / Tenascin C Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
TNC / Tenascin C Rabbit anti-Mouse Polyclonal (aa174-621) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
TNC / Tenascin C Rabbit anti-Human Polyclonal (C-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$750
Sandwich
96-Well Strip Plate
Pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Competitive EIA
96-Well Strip Plate
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich
96-Well Strip Plate
Human
10 - 250 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
Sandwich
12 x 8-Well Microstrips
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Human
93.7 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$632
E. coli
His, N-Terminal
51.8 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
TNC / Tenascin C Mouse anti-Human Monoclonal (T20) Antibody
Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$380
Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$598
E. coli
His
39.6 kD
20 µg/$323; 1 mg/$1,355; 100 µg/$420
293T Cells
Myc-DDK (Flag)
240.91 kDa
20 µg/$215
TNC / Tenascin C Rabbit anti-Human Polyclonal (aa1888-2201) (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
TNC / Tenascin C Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
TNC / Tenascin C Mouse anti-Human Monoclonal (3B4) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
TNC / Tenascin C Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
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